Home Tools

trans-ACPD

Catalog No. T3484 CAS 67684-64-4

Synonyms: Trans-(±)-ACP, 1-amino-1,3-dicarboxycyclopentane, (±)-trans-ACPD

trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor); active at the group I/II mGlu receptors (EC50: 2/15/23/800 μM, mGluR2/1/5/4).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

trans-ACPD, CAS 67684-64-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
2 mg	In stock	$ 57.00
5 mg	In stock	$ 91.00
10 mg	In stock	$ 150.00
25 mg	In stock	$ 293.00
50 mg	In stock	$ 531.00
100 mg	In stock	$ 768.00
1 mL * 10 mM (in DMSO)	In stock	$ 68.00

Bulk Inquiry

Select Batch

Purity: 99.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor); active at the group I/II mGlu receptors (EC50: 2/15/23/800 μM, mGluR2/1/5/4).
Targets&IC50	mGluR4:800 μM(EC50), mGluR5:23μM(EC50), mGluR1:15μM(EC50), mGluR2:2μM(EC50)
In vitro	Excitatory amino acid (EAA) analogues activate receptors that are coupled to the increased hydrolysis of phosphoinositides (PIs). Hippocampal slices are prepared from neonatal rats (6-11 days old) to characterize the effects of EAA analogues on these receptors in these studies. The concentration of trans-ACPD required to evoke half-maximal stimulation (EC50 value) is 51 μM. DL-2-Amino-3-phosphonopropionate (DL-AP3) is also equipotent as an inhibitor of PI hydrolysis stimulated by ibotenate, quisqualate, and trans-ACPD (IC50 values are 480-850 μM)[2].
In vivo	Intrathecal administration of NMDA, kainate, and trans-ACPD, along with the pro-inflammatory cytokines TNF-α or IL-1β, markedly increases biting behavior in mice, a paradigm shift from the control group receiving saline. Pre-systemic intervention with GM at a dosage of 100 mg/kg intraperitoneally notably decreases biting behavior in comparison to saline treatment (10 mL/kg, i.p.), with statistical significance (p<0.001). The efficacy of GM is particularly pronounced against pro-inflammatory cytokines and NMDA, exhibiting inhibition rates of TNF-α (92±7%), IL-1β (91±5%), NMDA (69±1%), and trans-ACPD (71±12%). Conversely, kainate-induced biting responses remain unaffected by GM at the same concentration.

Synonyms	Trans-(±)-ACP, 1-amino-1,3-dicarboxycyclopentane, (±)-trans-ACPD
Molecular Weight	173.17
Formula	C7H11NO4
CAS No.	67684-64-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

1eq. NaOH: 50 mM

H2O: 5 mM, Heating is recommended.

References and Literature

1. Linden DJ, et al. Trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons. J Neurophysiol. 1994 May;71(5):1992-8. 2. Littman L, et al. Multiple mechanisms for inhibition of excitatory amino acid receptors coupled to phosphoinositide hydrolysis. J Neurochem. 1992 Nov;59(5):1893-904. 3. Córdova, M., Martins, D., Silva, M., Baggio, C., Carbonero, E., & Ruthes, A. et al. (2013). Polysaccharide glucomannan isolated from Heterodermia obscurata attenuates acute and chronic pain in mice. Carbohydrate Polymers, 92(2), 2058-2064. doi: 10.1016/j.carbpol.2012.11.041

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Neurotransmitter Receptor Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Bioactive Compound Library Neuronal Signaling Compound Library Anti-Alzheimer's Disease Compound Library

Related Products

Related compounds with same targets

pep2-EVKI acetate(1315378-67-6 free base) DCB LY 456236 hydrochloride S-(4-Hydroxybenzyl)glutathione VU-1545 LY339434 HCl VU0361737 DMeOB

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

trans-ACPD 67684-64-4 Neuroscience GluR Trans-(±)-ACP transACPD 1-amino-1,3-dicarboxycyclopentane Trans-ACP Metabotropic glutamate receptors (±)-trans-ACPD trans ACPD mGluR Inhibitor inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.