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L-Cysteinesulfinic acid monohydrate

Catalog No. T41301 CAS 207121-48-0

L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1].

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L-Cysteinesulfinic acid monohydrate Chemical Structure

L-Cysteinesulfinic acid monohydrate, CAS 207121-48-0

Pack Size	Availability	Price/USD
10 mg	In stock	$ 39.00
25 mg	In stock	$ 79.00
50 mg	In stock	$ 122.00
100 mg	In stock	$ 178.00

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Biological Description

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Description

In vitro

L-Cysteinesulfinic acid (monohydrate) serves as an innate activator for the phospholipase D (PLD)-linked metabotropic excitatory amino acids (EAA) receptor, selectively triggering the PLD-associated mechanism. When applied to hippocampal slices, 1 mM concentrations of L-CSA (monohydrate) significantly enhance PLD activity, unlike similar doses of L-glutamate, L-aspartate, and L-HCA, which show no effect. Furthermore, L-CSA (monohydrate) prompts a dose-responsive elevation in PLD activity in these slices, even when iGluR antagonists are present, with the potency around an EC50 of 500 uM. Notably, the response to 1 mM L-CSA (monohydrate) in augmenting PLD activity remains unaltered by 1 uM tetrodotoxin, indicating that the effect is not reliant on an increase in neuronal activity[1].

Molecular Weight	183.18
Formula	C9H10FNO2
CAS No.	207121-48-0

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 120 mg/mL (701.06 mM), Sonication is recommended.

References and Literature

1. Shi Q, et al. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. J Pharmacol Exp Ther. 2003 Apr;305(1):131-42. 2. Boss V, et al. L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Mouse Metabolite Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Neurotransmitter Receptor Compound Library

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Keywords

L-Cysteinesulfinic acid monohydrate 207121-48-0 Neuroscience GluR L Cysteinesulfinic acid monohydrate LCysteinesulfinic acid monohydrate Metabotropic glutamate receptors Inhibitor inhibit L-Cysteinesulfinic acid Monohydrate L-Cysteinesulfinic acid mGluR inhibitor

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