mglu2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T15812	LY2979165	mGlu2 agonist	GluR
	LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.		GluR
T6022	LY404039	pomaglumetad	Glucocorticoid Receptor , GluR
	LY404039 (pomaglumetad) is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).		Glucocorticoid Receptor , GluR
T3451	JNJ-42153605		GluR
	JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).		GluR
T22638	CBiPES hydrochloride	CBiPES HCl	GluR
	CBiPES hydrochloride (CBiPES HCl) is a potent orthosteric modulator of the mGlu2 receptor with an EC50 value of 92.8 nM.CBiPES hydrochloride blocks the action of WT and mGlu(3) receptors.CBiPES hydrochloride can be used ...		GluR
T3010	Xanthurenic Acid	8-Hydroxykynurenic acid,4,8-Dihydroxyquinaldic acid,xanthurenate	Apoptosis , Endogenous Metabolite , GluR
	Xanthurenic Acid (8-Hydroxykynurenic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3).		Apoptosis , Endogenous Metabolite , GluR
T23010	MNI 137		Others , GluR
	MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.		Others , GluR
T23000	ML289	VU0463597,ML 289	GluR
	ML289 (VU0463597) is a potent, selective, and CNS-penetrant negative allosteric modulator of mGlu3 (IC50=0.66 μM), demonstrating over 15-fold selectivity compared to mGlu2 and showing no activity against mGlu5.		GluR
T61972	Pomaglumetad methionil hydrochloride	LY2140023 hydrochloride	GluR
	Pomaglumetad methionine hydrochloride (LY2140023 hydrochloride) is a methionine prodrug of LY404039 with oral activity. LY404039 is a selective mGlu2/3 receptor agonist. Pomaglumetad methionil hydrochloride (LY2140023 hy...		GluR
T20941	Cloransulam-methyl	Cloransulam methyl	Others
	Cloransulam-methyl is an effective herbicide that is often applied to soybean fields to control broadleaf weeds.Cloransulam-methyl is rapidly metabolised in the soybean plant but is present in the soil.CBiPES hydrochlori...		Others
T6726	VU0361737	ML-128,VU 0361737	GluR
	VU0361737 (ML-128) is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 is110 nM for rat receptors.It exhibits weak activity...		GluR
TQ0094	JNJ-40411813	ADX-71149	GluR
	JNJ-40411813 (ADX-71149) (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).		GluR
T15809	LY2812223		LIM Kinase
	LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).		LIM Kinase
T22955	LY487379 hydrochloride	LY 487379 hydrochloride	Others
	Positive allosteric modulator of mGlu2 receptors		Others
T29142	VU6001966	VU 6001966,VU-6001966
	VU6001966 is a potent and selective mGlu2 inhibitor (mGlu2 IC50 = 78 nM) and negative allosteric modulator. VU6001966 exhibits excellent central nervous system (CNS) penetration.
T34376	RO5488608	RO 5488608,RO-5488608
	RO5488608 is a new type of high-efficiency mGlu2/3 NAM.
T27680	JNJ-40068782	JNJ 40068782
	JNJ-40068782 is a potent, selective and systemically active positive allosteric modulator of the mGlu2 receptor.
T11906	LY 541850		GluR
	LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expres...		GluR
T23247	Ro 64-5229		Others
	mGlu2 antagonist		Others
T27686	JNJ-46356479	JNJ 46356479
	JNJ-46356479 is a Selective and Orally Bioavailable mGlu2 receptor Positive Allosteric Modulator (PAM). JNJ-46356479 showed mGlu2 PAM EC50=78 nM; mGlu2 PAM Emax (%) = 256.
T70619	LY2934747
	LY2934747 is a novel, potent, and systemically bioavailable mGlu2/3 receptor agonist, exhibiting both antipsychotic and analgesic properties in vivo.