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VU6001966

Catalog No. T29142 CAS 2009052-76-8

Synonyms: VU 6001966, VU-6001966

VU6001966 is a potent and selective mGlu2 inhibitor (mGlu2 IC50 = 78 nM) and negative allosteric modulator. VU6001966 exhibits excellent central nervous system (CNS) penetration.

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VU6001966, CAS 2009052-76-8

Pack Size	Availability	Price/USD	Quantity
5 mg	35 days	$ 760.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

VU6001966 is a potent and selective mGlu2 inhibitor (mGlu2 IC50 = 78 nM) and negative allosteric modulator. VU6001966 exhibits excellent central nervous system (CNS) penetration.

Synonyms	VU 6001966, VU-6001966
Molecular Weight	326.33
Formula	C17H15FN4O2
CAS No.	2009052-76-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Felts AS, Rodriguez AL, Smith KA, Engers JL, Morrison RD, Byers FW, Blobaum AL, Locuson CW, Chang S, Venable DF, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Emmitte KA. Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2. J Med Chem. 2015 Nov 25;58(22):9027-40. doi: 10.1021/acs.jmedchem.5b01371. Epub 2015 Nov 11. PubMed PMID: 26524606; PubMed Central PMCID: PMC4817271. 2. Bollinger KA, Felts AS, Brassard CJ, Engers JL, Rodriguez AL, Weiner RL, Hyekyung PC, Chang S, Bubser M, Jones CK, Blobaum AL, Niswender CM, Conn JP, Emmitte KA, Lindsley CW. Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core. ACS Med Chem. 2017 Aug 3. doi: 10.1021/acsmedchemlett.7b00279. [Epub ahead of print].

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

VU6001966 2009052-76-8 VU 6001966 VU-6001966 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.