mglu1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9021	Ro0711401	Ro-0711401,Ro 0711401	GluR
	Ro0711401 is an agonist of mGlu1 receptor.		GluR
T7292	FITM		GluR
	FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM).		GluR
T3478	Ro 67-7476		GluR
	Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.		GluR
T22954	LY 456236 hydrochloride	MPMQ hydrochloride	EGFR , GluR
	LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate w...		EGFR , GluR
T6871	L-Glutamic acid monosodium salt	Monosodium glutamate,Glutacyl,Glutavene,Ajinomoto,MSG	Apoptosis , Ferroptosis , GluR , iGluR
	L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.		Apoptosis , Ferroptosis , GluR , iGluR
T5512	JNJ16259685	.TN.T 16259685	GluR
	JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19 nM.		GluR
T6726	VU0361737	ML-128,VU 0361737	GluR
	VU0361737 (ML-128) is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 is110 nM for rat receptors.It exhibits weak activity...		GluR
T29118	VU 0469650	VU0469650,VU 0469650,VU-0469650,VU 0469650 HCl	GluR
	VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).		GluR
T34243	R214127	R 214127,R-214127
	R214127 is a new type of mGlu1 receptor high-affinity radioligand.
T23548	YM-298198 hydrochloride	YM 298198 hydrochloride	Others
	mGlu1 receptor antagonist		Others
T23545	YM 230888		Others
	Selective mGlu1 antagonist		Others
T22718	Desmethyl-YM 298198		Others
	mGlu1-selective antagonist		Others
T23238	Ro 01-6128		Others
	Positive allosteric modulator of mGlu1 receptors		Others
T23544	YM 202074		Others
	metabotropic glutamate receptor type 1 (mGlu1) antagonist		Others
T35081	VU0486321	VU 0486321,VU-0486321
	VU0486321 is a potent mGlu1 PAM with moderate rat PK (CLp = 13.3. mL/min/kg,t1/2 = 54 min), good free fraction (human fu = 0.05, rat fu =0.03) and excellent CNS penetration (Kp = 1.02).
T69489	YM-202074
	YM-202074 is a high affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. YM-202074 binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. It inhibits mGlu1-mediated inositol pho...
T21848	A 841720
	A-841720 is a potent, selective, and non-competitive antagonist of the mGlu1 receptor, exhibiting an IC 50 value of 10 nM specifically for the human mGlu1 receptor. It demonstrates a 34-fold greater selectivity for mGlu1...
T10978	DCG-IV		Others
	DCG-IV is an effective agonist of class II mGluR. DCG-IV has anticonvulsant and neuroprotective effects. The EC50 of mGlu2R and mGlu3R are 0.35 and 0.09 μM, respectively. DCG-IV is also a competitive antagonist of Group ...		Others
T23440	TC-N 22A		GluR
	TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier. EC50 expression of TC-N 22A in BHK cells expressing human mGlu4 was 9 nM. TC-N 22A showed very...		GluR
T71764	YM 298198 Hydrochloride
	YM 298198 Hydrochloride is a non-competitive antagonist with high affinity and selectivity for mGlu1 receptors (Ki = 19 nM). YM 298198 Hydrochloride is inactive at other mGlu receptor subtypes (mGlu2-7), ionotropic recep...