Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier. EC50 expression of TC-N 22A in BHK cells expressing human mGlu4 was 9 nM. TC-N 22A showed very low activity against mGlu 1, 2, 3, 5, and 7 receptors in excitation and forward allosteric models (EC50 <10 μM). TC-N 22A can be used in the study of central nervous system diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 123.00 | |
5 mg | In stock | $ 263.00 | |
10 mg | In stock | $ 325.00 | |
25 mg | In stock | $ 548.00 | |
50 mg | In stock | $ 788.00 | |
100 mg | In stock | $ 1,080.00 |
Description | TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier. EC50 expression of TC-N 22A in BHK cells expressing human mGlu4 was 9 nM. TC-N 22A showed very low activity against mGlu 1, 2, 3, 5, and 7 receptors in excitation and forward allosteric models (EC50 >10 μM). TC-N 22A can be used in the study of central nervous system diseases. |
Targets&IC50 | mGlu1/2/3/5/7 receptors:>10 μM (EC50), mGlu4 receptor:9 nM (EC50) |
Molecular Weight | 283.35 |
Formula | C14H13N5S |
CAS No. | 1314140-00-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (176.46 mM)
You can also refer to dose conversion for different animals. More
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TC-N 22A 1314140-00-5 Neuroscience GluR TCN 22A TC N 22A inhibitor inhibit