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Neuroscience AChR Umeclidinium bromide

Umeclidinium bromide

Catalog No. T4997   CAS 869113-09-7
Synonyms: GSK573719A, GSK573719A

Umeclidinium bromide is a novel mAChR antagonist.

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Umeclidinium bromide, CAS 869113-09-7
Pack Size Availability Price/USD Quantity
2 mg In stock 54.00
5 mg In stock 77.00
10 mg In stock 126.00
25 mg In stock 223.00
50 mg In stock 369.00
100 mg In stock 553.00
200 mg In stock 829.00
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Purity 99.09%
Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Umeclidinium bromide is a novel mAChR antagonist.
Targets&IC50 M1 mAChR ,   M2 mAChR ,   M3 mAChR ,   M4 mAChR ,   M5 mAChR
Animal Research
Mice:Age-matched male BALB/c mice (23-25 gm) are pretreated intranasally (50 μL per mouse) with vehicle (0.9% saline) or Umeclidinium bromide at intervals (0.25-48 hours) prior to methacholine challenge, and placed into individual plethysmograph chambers. Fresh air is supplied by bias flow pumps to the chambers. After baseline respiratory [enhanced pause (Penh)] values are collected, the mice received methacholine (30 mg/mL or EC80) by aerosol delivery (flow=1.6 mL/min×2 minutes). An average Penh is then calculated for 5 minutes. Penh=[(expiratory time/relaxation time)?1]×(peak expiratory flow/peak inspiratory flow), and relaxation time is the amount of time required for 70% of the tidal volume to expire. In some cases, animals are treated on multiple, consecutive days as described in the figure legends. The data are expressed as the mean±S.E.M. percent inhibition of Penh or (mean Penh value of vehicle treated group-Penh for each drug-treated animal) divided by (mean Penh value of vehicle treated group)×100%. Data are analyzed using commercially available software.
Synonyms GSK573719A , GSK573719A
Purity 99.09%
Molecular Weight 508.49
Formula C29H34BrNO2
CAS No. 869113-09-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 34 mg/mL (66.86 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Cazzola M, et al. Pharmacology and therapeutics of bronchodilators. Pharmacol Rev. 2012 Jul;64(3):450-504. 2. Calzetta L, et al. Pharmacological characterization of the interaction between umeclidinium and vilanterol in human bronchi. Eur J Pharmacol. 2017 Jul 14. pii: S0014-2999(17)30470-3. 3. Salmon M, et al. Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases. J Pharmacol Exp Ther. 2013 May;345(2):260-70.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Clinical Compound Library Neuronal Signaling Compound Library FDA-Approved Drug Library Immunology/Inflammation Compound Library GPCR Compound Library Anti-Cardiovascular Disease Compound Library Drug Repurposing Compound Library Neurotransmitter Receptor Compound Library Target-Focused Phenotypic Screening Library Anti-Neurodegenerative Disease Compound Library NMPA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Anti-Parkinson's Disease Compound Library

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