imatinib — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6230	Imatinib	STI571,CGP057148B,ST-1571	SARS-CoV , Bcr-Abl , PDGFR , c-Kit , Autophagy
	Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kit with oral activity. Imatinib has antitumor activity for the tre...		SARS-CoV , Bcr-Abl , PDGFR , c-Kit , Autophagy
T11641	N-Desmethyl imatinib	Imatinib metabolite N-Desmethyl imatinib,Norimatinib	Bcr-Abl , PDGFR , c-Kit , Drug Metabolite
	N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.		Bcr-Abl , PDGFR , c-Kit , Drug Metabolite
T1621	Imatinib Mesylate	ST-1571 Mesylate,STI-571,CGP-57148B	Bcr-Abl , PDGFR , c-Kit , Autophagy
	Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR, respectively).		Bcr-Abl , PDGFR , c-Kit , Autophagy
T67847	Imatinib impurities3		Bcr-Abl , PDGFR , c-Kit
	Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively.		Bcr-Abl , PDGFR , c-Kit
T40504	N-Desmethyl imatinib mesylate	ImatinibmetaboliteN-Desmethylimatinibmesylate,N-Desmethyl imatinib mesylate,Norimatinib mesylate
	Norimatinib mesylate, also known as N-Desmethyl imatinib mesylate, is a metabolite derived from Imatinib, which acts as a potent multi-target inhibitor of v-Abl, c-Kit, and PDGFR.
T19451	N-Desmethyl imatinib-d8	Norimatinib D8,Imatinib metabolite N-Desmethyl imatinib D8,N-Desmethyl imatinib D8	Others
	N-Desmethyl imatinib D8 is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib.		Others
T22859	Imatinib hydrochloride		Others
	Imatinib is a multi-target inhibitor of v-Abl, c-Kit, and PDGFR (IC50: 0.6 μM, 0.1 μM, and 0.1 μM, respectively). Imatinib is used to treat chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs), and...		Others
T19015	Imatinib Acid		Others
	Imatinib Acid is usually used as a fluorescent probe or labeled chemical.		Others
T11639	Imatinib D4	CGP-57148B D4,STI571 D4	Others
	Imatinib D4 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.		Others
T11640	Imatinib-d8	CGP-57148B D8,STI571 D8	Others
	Imatinib D8 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.		Others
T18592	Imatinib carbaldehyde	CGP-57148B carbaldehyde,STI571 carbaldehyde,PROTAC ABL binding moiety 1	Others
	Imatinib carbaldehyde (also known as CGP-57148B carbaldehyde) is a compound derived from Imatinib, an inhibitor of the ABL protein. Imatinib carbaldehyde binds to the IAP ligand with the assistance of a linker, resulting...		Others
T73973	Imatinib Impurity E
	Imatinib Impurity E is a specific impurity found in Imatinib, an orally available inhibitor of multiple tyrosine kinases, including BCR/ABL, v-Abl, PDGFR, and c-kit. Imatinib (STI571) operates by semi-competitively inhib...
T64338	AKI603	AKI 603,AKI-603	Aurora Kinase
	AKI603 is a novel small molecule inhibitor of Aurora kinase A (AurA)(IC50 = 12.3 nM). AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in l...		Aurora Kinase
T3071	Olverembatinib	GZD 824	Bcr-Abl
	Olverembatinib (GZD 824) is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT, IC50: 0.34 nM) and Bcr-Abl(T315I, IC50: 0.68 nM).		Bcr-Abl
T2429	Olverembatinib dimesylate	GZD824 Dimesylate,HQP1351	Bcr-Abl
	Olverembatinib dimesylate (GZD824 Dimesylate) is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I).		Bcr-Abl
T1448L	Dasatinib monohydrate	BMS-354825 Monohydrate	Apoptosis , Bcr-Abl , Src , c-Kit , Ephrin Receptor , Autophagy
	Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activit...
T27555	HS-438	HS 438
	HS-438 inhibits imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia.
T71144	Nilotinib N-oxide
	Nilotinib N-oxide is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia.
T23617	Aclacinomycin	Aclacinomycins,Siwenmycin
	Aclacinomycin A is an anthracycline drug. It sensitizes K562 chronic myeloid leukemia cells to imatinib through p38MAPK-mediated erythroid differentiation. It is used in the treatment of cancer.
T18694	SNIPER(ABL)-050		Others
	SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker. This conjugation results in the reduction of BCR-ABL protein[1].		Others