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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9164 | BMS-986242 | BMS986242 | IDO , Indoleamine 2,3-Dioxygenase (IDO) |
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer. | |||
T9054 | RO6889678 | HBV | |
RO6889678 is HBV inhibitor with a complex ADME profile. | |||
T4706 | Uridine-5'-diphosphate disodium salt | UDP disodium salt,Uridine 5'-diphosphate disodium salt hyd | DNA/RNA Synthesis , Endogenous Metabolite , P2Y Receptor |
Uridine-5'-diphosphate disodium salt (UDP disodium salt) is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstriction... | |||
T3397 | Epmedin C | Baohuoside-VI,Epimedin C | Others |
Epmedin C (Baohuoside-VI) was metabolized via desugarization, dehydrogenation, hydrogenation, dehydroxylation, hydroxylation, demethylation and glucuronidation pathways in vivo. It has potential activity against osteopor... | |||
TJO2758 | D-Glucuronic acid | Aldehydo-D-Glucuronic Acid | Others , Endogenous Metabolite |
D-Glucuronic acid (Aldehydo-D-Glucuronic Acid) is a carboxylic acid with structural similarity to glucose with detoxifying activity. The xenobiotic metabolism of various substances such as drugs, pollutants, bilirubin, a... | |||
T4809 | Pyrimidine | Metadiazine | Others , Endogenous Metabolite |
Pyrimidine (Metadiazine)s are heterocyclic, six-membered, nitrogen-containing carbon ring structures, with uracil, cytosine and thymine being the basal structures of ribose-containing nucleosides (uridine, cytidine, and ... | |||
T6S1559 | Aurantio-obtusin | Others | |
1. Biotransformation of glucoAurantio-obtusin towards Aurantio-obtusin increased the toxicity of irinotecan through increased inhibition of SN-38 glucuronidation. 2. Aurantio-obtusin, stimulated chemotactic migration of ... | |||
T37004 | Estradiol 3-sulfate 17β-Glucuronide (potassium salt) | ||
Estradiol 3-sulfate is a sulfated form of the steroid hormone 17β-estradiol , and is common in fetal plasma and in the breast tissues of patients with mammary carcinoma. Sulfated estrogens, including estradiol 3-sulfate,... | |||
T37852 | Chlorzoxazone N-Glucuronide | ||
Chlorzoxazone N-glucuronide is a phase II metabolite of the skeletal muscle relaxant chlorzoxazone . Chlorzoxazone N-glucuronide is formed via glucuronidation of chlorzoxazone by the UDP-glucuronosyltransferase (UGT) iso... | |||
T36826 | Acetaminophen Glucuronide (sodium salt) | ||
Acetaminophen glucuronide is an inactive metabolite of the analgesic and antipyretic agent acetaminophen . It is formed via glucuronidation of acetaminophen by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A... | |||
T35845 | (R,S)-Carvedilol Glucuronide | ||
(R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide. (R)-Carvedilol glucuronide is formed via glucuronidation of (R)-carvedilol by the... | |||
T16279 | Nebicapone | BIA 3-202 | Others |
Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor and is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to ... | |||
T35621 | Febuxostat Acyl Glucuronide | ||
Febuxostat acyl glucuronide is a metabolite of the xanthine oxidoreductase inhibitor febuxostat . Febuxostat acyl glucuronide is formed via glucuronidation of febuxostat by uridine diphosphate-glucuronosyltransferases (U... | |||
T35720 | 4’-hydroxy Atomoxetine Glucuronide (hydrate) | ||
4’-hydroxy Atomoxetine glucuronide is a metabolite of the norepinephrine transporter (NET) inhibitor atomoxetine .1It is formed from atomoxetine by glucuronidation of the intermediate metabolite 4-hydroxy atomoxetine.2 1... | |||
T35440 | (-)-Sitagliptin Carbamoyl Glucuronide | ||
(-)-Sitagliptin carbamoyl glucuronide is a minor phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin . (-)-Sitagliptin carbamoyl glucuronide is formed by N-carbamoyl glucuronidation and ha... | |||
T37378 | Propofol β-D-Glucuronide | ||
Propofol β-D-glucuronide is a metabolite of propofol sulfate , a short-acting anesthetic agent. [1] [2] The metabolite is generated through the glucuronidation of propofol by uridine diphosphate glucuronosyltransferases.... | |||
T36794 | Dolutegravir O-β-D-Glucuronide | ||
Dolutegravir O-β-D-glucuronide is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed from dolutegravir primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1in vivobut is also metabolized ... |