20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0320 | Colchicine | Colcin,Colchineos,Colchisol | Apoptosis , Microtubule Associated , Autophagy |
Colchicine (Colcin) is a natural product that is an inhibitor of microtubule polymerization (IC50=3 nM) and blocks microtubule polymerization by binding to microtubule proteins. Colchicine can be used in the treatment of... | |||
T30999 | Colchicine, deacetamido-5,6-didehydro- | Deacetamido-6-dehydrocolchicine,Colchicine,deacetamido-6-dehydro- (7CI) | |
Colchicine, deacetamido-5,6-didehydro- is a biochemical. | |||
T31000 | Colchicine, N-deacetyl-10-thio- | N-Deacetylthiocolchicine,Desacetyl thiocolchicine,Deacetylthiocolchicine | |
Colchicine, N-deacetyl-10-thio- is a biochemical. | |||
T41248 | Thiocolchicine | Microtubule Associated | |
Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology. | |||
T9812 | Tubulin inhibitor 24 | Microtubule Associated | |
Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization. | |||
TN6706 | 3-demethylcolchicine | Reactive Oxygen Species | |
3-demethylcolchicine is a natural product isolated from Gloriosa superba.Inhibitory effect on the polymerization of purified bovine brain tubulin. | |||
T15012 | Crolibulin | EPC2407 | Microtubule Associated |
Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization. | |||
T31906 | Gamma-Lumicolchicine | ||
gamma-Lumicolchicine is three, alpha, beta, and gamma isomers of ultraviolet degradation products of colchicine that lack many of the physiological actions of the parent; used as experimental control for colchicine actio... | |||
T32946 | Lumicolchicine | ||
Lumicolchicine is a bioactive chemical. | |||
T31244 | Deacetylisocolchicine | ||
Deacetylisocolchicine is a biochemical. | |||
T31255 | Deacetylthiocolchicine hydrochloride | Deacetylthiocolchicine chlorhydrate,Deacetylthiocolchicine HCl | |
Deacetylthiocolchicine hydrochloride is a biochemical. | |||
T72544 | 4-Formylcolchicine | ||
4-Formylcolchicine, a potent anticancer agent, demonstrates cytotoxicity with IC 50 values of 1.007 µM for A549 cells, 0.128 µM for HT-29 cells, and 0.054 µM for HCT116 cells. | |||
TN7063 | N-Acetaminophen | NSC 403155,N-Acetyldemecolcine,N-Methylcolchicine,N-Acetylcolchamine | Others |
N-Acetaminophen (N-Methylcolchicine) is a methylated form of Colchicine. | |||
T77647 | Tubulin polymerization-IN-43 | Apoptosis , Microtubule Associated | |
Tubulin polymerization-IN-43 is an inhibitor of tubulin polymerisation.Tubulin polymerization-IN-43 has multiple effects, disrupting the cellular microtubule network by targeting the colchicine locus and promoting cell c... | |||
T60009 | YS-370 | P-gp | |
YS-370 is an orally active inhibitor of P-gp and shows moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance to paclitaxel and colchicine and exhibits stronger antitumor activity in combina... | |||
T67935 | Tubulin inhibitor 11 | Apoptosis , Microtubule Associated | |
Tubulin Inhibitor 11 is a potent, orally active agent that inhibits tubulin by targeting the Colchicine binding site. It impedes tubulin polymerization, leading to mitotic blockade and apoptosis. | |||
T9595 | LP-261 | Microtubule Associated | |
LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest. | |||
T28886 | Suprafenacine | N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide | Microtubule Associated |
Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) is a cell-permeable microtubule destabilizer that induces cell cycle arrest and apoptosis in G2/M phase. Suprafenacine ... | |||
T65128 | Tartaric acid disodium dihydrate | Disodium L-(+)-Tartrate Dihydrate | Phosphatase , Endogenous Metabolite |
Tartaric acid disodium dihydrate (Disodium L-(+)-Tartrate Dihydrate) is commonly used as a buffer in molecular biology and cell culture.Tartaric acid disodium dihydrate is an acid phosphatase inhibitor that increases the... | |||
T2511 | Plinabulin | NPI-2358 | Microtubule Associated |
Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, the... |