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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11481 | GSK2239633A | CCR | |
GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4. | |||
T10297L | AMG 487 | CXCR | |
AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. | |||
T30258 | AZD-4818 | CCR1 antagonist | CCR |
AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease. | |||
T4300 | AZD2098 | CCR | |
AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research. | |||
T7499 | TAK-779 | Takeda 779 | HIV Protease , CXCR , CCR |
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3). | |||
TQ0103 | INCB3344 | CCR | |
INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8 nM (mCCR2) and in 3.8 nM (hCCR2) antagonism of chemotaxis act... | |||
T5849 | JMS-17-2 | CXCR | |
JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM). | |||
T4674 | SB297006 | SB 297006 | CCR |
SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of ... | |||
T17225 | Vercirnon | CCX282-B,GSK-1605786,Traficet-EN | CCR |
Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases. | |||
T7681 | AZD-5069 | CXCR | |
AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM). | |||
T3047 | SRT3109 | CXCR | |
SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions. | |||
T1955 | SB225002 | CXCR | |
SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2. | |||
T5384 | RS 504393 | CCR | |
RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1). | |||
TQ0283 | RS102895 | CCR | |
RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1. | |||
T1739 | WZ811 | CXCR | |
WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM). | |||
T4163 | Reparixin | DF 1681Y,Repertaxin | CXCR |
Reparixin (Repertaxin) is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM). | |||
T3992 | MSX-122 | MSX 122,MSX122 | CXCR |
MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM). | |||
T17208 | USL311 | CXCR | |
USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. USL311 inhibits CXCR4 activation and decreases proliferation and migration of CXCR4-expressing... | |||
T5193 | Danirixin | GSK1325756 | CXCR |
Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM). | |||
T2477 | UNBS5162 | UNBS 5162,UNBS-5162 | CXCR , Autophagy |
UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers. |