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AZD-5069

Name: AZD-5069
Brand: TargetMol
SKU: T7681
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7681Cas No. 878385-84-3

AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).

AZD-5069

🥰Excellent

Purity: 98.63%

Catalog No. T7681Cas No. 878385-84-3

AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).

Pack Size	Price	Availability
1 mg	$46	In Stock
2 mg	$59	In Stock
5 mg	$77	In Stock
10 mg	$126	In Stock
25 mg	$239	In Stock
50 mg	$369	In Stock
100 mg	$549	In Stock
500 mg	$1,190	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock

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Purity:98.63%

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COA

Product Introduction

Bioactivity

Description	AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).
Targets&IC50	CXCR2:0.79 nM
In vitro	AZD5069 inhibited neutrophil chemotaxis, with a pA2 of approximately 9.6, and adhesion molecule expression, with a pA2 of 6.9, in response to CXCL1[1]

Chemical Properties

Molecular Weight	476.52
Formula	C₁₈H₂₂F₂N₄O₅S₂
Cas No.	878385-84-3
Smiles	C[C@@H](Oc1cc(NS(=O)(=O)N2CCC2)nc(SCc2cccc(F)c2F)n1)[C@@H](O)CO
Relative Density.	1.56 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (188.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0985 mL	10.4927 mL	20.9855 mL	104.9274 mL
5 mM	0.4197 mL	2.0985 mL	4.1971 mL	20.9855 mL
10 mM	0.2099 mL	1.0493 mL	2.0985 mL	10.4927 mL
20 mM	0.1049 mL	0.5246 mL	1.0493 mL	5.2464 mL
50 mM	0.0420 mL	0.2099 mL	0.4197 mL	2.0985 mL
100 mM	0.0210 mL	0.1049 mL	0.2099 mL	1.0493 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc