agonism — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12855	SB 258719		5-HT Receptor
	SB 258719 is a selective antagonist of 5-HT7 receptor(pKi of 7.5).		5-HT Receptor
T8706	STAMBP-IN-1		Others
	STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after TLR agonism.		Others
T75720	Thrombospondin-1 (1016-1023) (human, bovine, mouse)		Apoptosis
	Thrombospondin-1 (1016-1023) (human, bovine, mouse) is part of Thrombospondin-1 (TSP-1), a peptide with CD47 agonism.		Apoptosis
TP1617L	Chemerin-9 (149-157) acetate	Chemerin-9 (149-157) acetate (676367-27-4 free base)	Others
	Chemerin-9 (149-157) acetate, The nonapeptide 149,YFPGQFAFS157 (chemerin-9), corresponding to the C terminus of processed chemerin, retained most of the activity of the full-size protein, with regard to agonism toward th...		Others
T4093	Fabomotizole hydrochloride	Afobazole hydrochloride,CM346 hydrochloride	MAO
	Fabomotizole hydrochloride (CM346 hydrochloride), an anxiolytic drug, produces anxiolytic and neuroprotective effects. The mechanism of Afobazole remains poorly defined, however, with GABAergic, NGF, and BDNF release pro...		MAO
T36520	COR659		Cannabinoid Receptor , GABA Receptor
	COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effects via a composite mechanism, including positive allosteri...		Cannabinoid Receptor , GABA Receptor
T23794	BIO592	BIO-592,BIO 592
	BIO592 is a modulator of RORγt. BIO592 triggers inverse agonism of RORγ.
T23662	Aganodine	Aganodin
	Aganodine is a guanidine that activates presynaptic imidazoline receptors. Aganodine inhibits the presynaptic release of norepinephrine through its agonism at imidazoline receptors.
T27489	GSK-7227	GSK7227,GSK 7227
	GSK-7227, a novel class of PPARdelta partial agonists, shows potent partial agonism of the PPARdelta target genes CPT1a and PDK4 in skeletal muscle cells.
T16396	OP-3633		Others
	OP-3633 is an effective and selective steroidal glucocorticoid receptor (GR) antagonist (IC50: 29 nM). OP-3633 shows low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism. It also has an inhibition...		Others
TP1617	Chemerin-9 (149-157)	Chemerin-9 149-157
	The nonapeptide 149,YFPGQFAFS157 (chemerin-9), corresponding to the C terminus of processed chemerin, retained most of the activity of the full-size protein, with regard to agonism toward the chemerinR.the natural ligand...
T70379	PF-04479745 tartrate
	PF-04479745, also known as PF-4479745, is a potent and selective 5-HT2C agonist (EC50 = 10 nM). PF-4479745 displayed robust pharmacology in a preclinical canine model of stress urinary incontinence (SUI) and no measura...
T70073	Fabomotizole dihydrochloride
	Fabomotizole, also known as Afobazole, Obenoxazine and CM346, is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant action...
T68881	OL-135
	OL-135 is a CNS penetrant, highly potent and selective reversible inhibitor of FAAH. OL-135 exhibits analgesic pharmacology in various animal models without the motor impairment associated with direct CB1 agonism.
T71707	Romergoline
	Romergoline, a newly synthesized ergoline-derivative, shows a unique pharmacological profile, displaying a full dopamine (DA) antagonism in normal animals but a full DA agonism in"denervated" animal models.
T62722	SC13
	SC13, a novel mitragynine analog, exhibits low-efficacy agonism at Mu opioid receptors and provides antinociception while minimizing adverse effects.
T71963	(−)-WIN 55,212-3 mesylate
	(−)-WIN 55,212-3 mesylate is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor, blocking both the stimulating action of CP 55,940 and the inverse agonism ...
TP1435	Chemerin-9 (149-157) TFA(676367-27-4 free base)	Chemerin-9 (149-157) (TFA)
	Chemerin-9 (149-157) TFA, the nonapeptide (149)YFPGQFAFS(157) (chemerin-9), corresponding to the C terminus of processed chemerin, retains most of the activity of the full-size protein, with regard to agonism toward the ...
T78778	D3R/MOR antagonist 1		Dopamine Receptor
	Compound 114 (D3R/MOR antagonist 1) exhibits dual antagonistic activity at dopamine D3 receptors (D3R) and mu-opioid receptors (MOR), with K i values of 46.5 nM and 691 nM, respectively. It offers analgesic benefits thro...		Dopamine Receptor
T79547	MOR agonist-2		Opioid Receptor
	Compound 46, designated as MOR agonist-2, serves as a D3R antagonist and a MOR agonist with respective K i values of 7.26 nM and 564 nM. This compound holds potential for analgesic effects attributed to its partial agoni...		Opioid Receptor