abrogates — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6157	Devimistat	CPI-613,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid	Apoptosis , Dehydrogenase , Mitochondrial Metabolism
	Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potent...		Apoptosis , Dehydrogenase , Mitochondrial Metabolism
T7830	Windorphen		Wnt/beta-catenin
	Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling.		Wnt/beta-catenin
T29087	VA-K-14 hydrochloride	VAK14 Hydrochloride,VA K 14 HCl,VA-K-14 HCl,VAK14 HCl	TSH Receptor
	VA-K-14 hydrochloride（VAK14 HCl） is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogate...		TSH Receptor
T7771	Brilliant Blue FCF	FD&C Blue No. 1,Erioglaucine disodium salt,Acid Blue 9,E133	Others
	Brilliant Blue FCF (Erioglaucine disodium salt) is a nontoxic dye for saphenous vein graft marking that abrogates response to injury.		Others
T68455	AP23846	AP-23846	Src
	AP23846 is a novel and potent Src family kinase inhibitor that reduces vascular endothelial growth factor and interleukin-8 expression and abrogates downstream angiogenic processes in human solid tumor cell lines.		Src
T26629	Angstrom6	A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide	PAI-1
	Angstrom6 (A-6 peptide) is an 8 amino acid peptide derived from single chain urokinase fibrinogen activator (scuPA) that interferes with the uPA/uPAR cascade and abrogates the downstream effects.Angstrom6 has antitumor a...		PAI-1
T21792	CGP 3466B maleate	Omigapil (Maleate),Omigapil maleate	Apoptosis
	CGP 3466B maleate (Omigapil maleate) is an orally bioavailable GAPDH nitrosylation inhibitor. Omigapil maleate abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil male...		Apoptosis
T73499	NG-497	NG497	Lipase
	NG-497 is a selective, small molecule inhibitor of human adipose triglyceride lipase (ATGL) that targets the enzymatically active patatin-like structural domain of human ATGL.NG-497 binds ATGL in a hydrophobic lumen adja...		Lipase
T14904	CCT244747		Chk
	CCT244747 is a CHK1 inhibitor (IC50: 7.7 nM) and also abrogates G2 checkpoint (IC50: 29 nM).		Chk
T70844	CM-118
	CM-118 is a potent and selective dual inhibitor of c-Met and ALK which potently abrogates hepatocyte growth factor (HGF)-induced c-Met phosphorylation and cell migration, as well as phosphorylation of ALK, EML4-ALK, and ...
T68895	CBP-93872
	CBP-93872 is a G2 checkpoint inhibitor. CBP-93872 specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint through inhibiting maintenance. CBP-93872 is an inhibitor of maintenance of the DSB-speci...
T70994	TAK-659 HCl
	TAK-659 is an inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Spleen tyrosine kinase inhibitor TAK-659 may inhibit the activity of syk, which ...
T36961	Malformin C
	Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human...
T69723	Taminadenant mesylate
	Taminadenant, also known as PBF-509 and NIR-178, is a potent and orally active adenosine A2A receptor antagonist with potential antineoplastic activity. PBF-509 selectively binds to and inhibits A2AR expressed on T lym...
T69682	AEW541 HCl
	AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NV...
T37602	GSK 143
	Spleen tyrosine kinase (Syk) inhibitor (pIC50 = 7.5). Also inhibits phosphorylated Erk (pIC50 = 7.1). Decreases cell number and viability in chronic lymphocytic leukemia (CCL) cell lines. Liddle et al (2011) Discovery of...