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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8496 | MAZ51 | Apoptosis , VEGFR | |
MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor. | |||
T9929 | Ramucirumab | VEGFR | |
Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors. | |||
T3S0335 | Soyasaponin Bb | Soyasaponin I | NF-κB , Caspase |
1. Soyasaponin Bb (Soyasaponin I) can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-kappaB and activating PETEN and caspase-3 signa... | |||
T72924 | VEGFR-3-IN-1 | VEGFR | |
VEGFR-3-IN-1 is a novel potent and selective VEGFR3 inhibitor with an IC50 of 110.4 nM.VEGFR-3-IN-1 possesses antitumor activity, inactivates the VEGFR3 signaling pathway, and inhibits the proliferation and migration of ... | |||
T3708 | BP-1-102 | STAT | |
BP-1-102 is an orally active, effective and specific STAT3 inhibitor. BP-1-102 binds Stat3 (Kd: 504 nM), then blocks Stat3-phosphotyrosine (pTyr) peptide interactions and Stat3 activation (4-6.8 μM), and selectively inhi... | |||
T3S2344 | β,β-Dimethylacrylshikonin | Dimethylacrylshikonin,β, β-Dimethylacrylshikonin | ERK , HIF/HIF Prolyl-Hydroxylase |
1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significant... | |||
T28899 | T-1840383 | ||
T-1840383 is an inhibitor of VEGF-induced VEGFR-2 phosphorylation and HGF-induced c-Met phosphorylation in vascular endothelial cells and cancer epithelial cells. | |||
T71930 | APKC-I | ||
aPKC-I is an inhibitor of atypical protein kinase C (aPKC ) which inhibits both PKCζ and PKCι with high specificity and prevents VEGF-induced endothelial permeability in cell culture and in vivo, thereby blocking ischemi... | |||
T80595 | Conbercept | KH902 | VEGFR |
Conbercept (KH902) is a fusion protein comprising the second immunoglobulin C-like domain of FLT1 and the third and fourth immunoglobulin C-like domains of KDR, linked to the Fc fragment of IGHG1. This monoclonal antibod... | |||
T71204 | Apatinib HC | Rivoceranib HCl,YN-968D1 HCl | |
Apatinib, also known as Rivoceranib and YN-968D1, is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. The free-base form is also known... | |||
T21387 | Nafoxidine HCl(1845-11-0 Free base) | PNU-0011100,PNU0011100,CP5600,CP 5600,CP-5600,PNU 0011100,Nafoxidine HCl | |
Nafoxidine is a partial estrogen antagonist. It inhibits angiogenesis in some tissues by blocking the effects of VEGF and FGF; paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces calcium... | |||
T69354 | Enzastaurin 2HCl | ||
Enzastaurin 2HCl, also known as DB-102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, Enzastaurin 2HCl selectively inhibits protein ki... | |||
T74422 | Sozinibercept | ||
Sozinibercept (OPT 302; VGX-300) is a soluble form of Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) that potently inhibits the activity of Vascular Endothelial Growth Factor-C and -D (VEGF-C/D), key proangiogen... | |||
T71853 | Enzastaurin HCl | ||
Enzastaurin HCl, also known as DB-102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, Enzastaurin HCl selectively inhibits protein kina... | |||
T37079 | VEGFR2 Kinase Inhibitor II | ||
Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms... | |||
T27033 | CKD-712 | CKD 712,CKD712 | |
CKD-712 is a nuclear factor NF-kappa B inhibitor. CKD-712 suppressed MMP-9, but not MMP-2 and other NF-κB-regulated proteins involved in cancer metastasis such as VEGF. CKD-712 induced cell cycle arrest at G2M phase by s... | |||
T61604 | PKC-IN-4 | ||
PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), exhibiting an IC 50 value of 0.52 μM. In vitro studies have demonstrated that PKC-IN-4 effectively suppresses NF-... | |||
T71180 | Oglufanide disodium | ||
Oglufanide disodium is t he disodium salt of a synthetic form of a naturally-occurring dipeptide consisting of L-glutamic acid and L-tryptophan with potential antiangiogenic and potential immunomodulating activities. Ogl... | |||
T83741 | S7 TFA | Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH | |
S7, a peptide antagonist of the IL-6 receptor, concentration-dependently inhibits IL-6 binding to its receptor. At 50 µM, S7 suppresses IL-6-triggered elevations in VEGF levels within C-33 A cervical cancer cells and RPM... | |||
T73516 | EVT801 | ||
EVT801 is an orally active, selective VEGFR-3 inhibitor (IC 50 = 11 nM) with demonstrated antitumor properties. It effectively suppresses VEGF-C-induced human endothelial cell proliferation and tumor (lymphatic) angiogen... |