trpa1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T77511	TRPA1-IN-2		TRP/TRPV Channel
	TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.		TRP/TRPV Channel
T39935	TRPA1-IN-1	TRPA1-IN-1
	TRPA1-IN-1 is a potent, selective antagonist of the TRPA1 channel, demonstrating significant oral bioavailability as a small molecule.
T40822	TRPA1 Antagonist 3	TRPA1 Antagonist 3
	TRPA1 Antagonist 3 is a compound with photoswitchable properties that acts as an agonist on the TRPA1 channel, providing the ability for optical control.
T13212	TRPA1 Antagonist 1		TRP/TRPV Channel
	TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.		TRP/TRPV Channel
T6617	Optovin		TRP/TRPV Channel
	Optovin is a TRPA1 activator, which is reversibly photoactivated.		TRP/TRPV Channel
T64337	PF-04745637	PF4745637,PF 4745637,PF 04745637,PF-4745637	TRP/TRPV Channel
	PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].		TRP/TRPV Channel
T4385	PF-4840154		TRP/TRPV Channel
	PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively.		TRP/TRPV Channel
T15628	JT010		TRP/TRPV Channel
	JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).		TRP/TRPV Channel
T7205	A-967079		TRP/TRPV Channel
	A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively.		TRP/TRPV Channel
T7430	AM-0902		TRP/TRPV Channel
	AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).		TRP/TRPV Channel
T8307	Hydroxy-α-sanshool	Hydroxy-α-sanshool	Endogenous Metabolite , TRP/TRPV Channel
	Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).		Endogenous Metabolite , TRP/TRPV Channel
T12514	Podocarpic acid		Others , TRP/TRPV Channel
	Podocarpic acid is a natural product and a novel TRPA1 activator.		Others , TRP/TRPV Channel
TQ0001	1,4-Cineole	Isocineole	Endogenous Metabolite , TRP/TRPV Channel
	1,4-Cineole (Isocineole) is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.		Endogenous Metabolite , TRP/TRPV Channel
T2711	Chembridge-5861528	TCS 5861528	TRP/TRPV Channel
	Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively.		TRP/TRPV Channel
T8410	ASP7663		TRP/TRPV Channel
	ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.		TRP/TRPV Channel
T29968	AMG-0347	UNII-CD7L9290QR	TRP/TRPV Channel
	AMG-0347 (UNII-CD7L9290QR) is a small molecule inhibitor targeting TRPA1(transient receptor potential ankyrin 1) ion channels, a receptor found in sensory neurons and involved in the detection of pain and environmental s...		TRP/TRPV Channel
T21543	AP 18		TRP/TRPV Channel
	AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 could reverse complete ...		TRP/TRPV Channel
TN3575	(±)-Cannabichromene	Cannabichromene,Cannabichrome	Cannabinoid Receptor
	(±)-Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1), it selectively reduces inflammation-induced hy...		Cannabinoid Receptor
T22920	LE135	LE 135	Retinoid Receptor
	LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), and has a higher affinity to RARβ. LE135 is highly selective over RARγ, RXRα, RXRβ and RXRγ. LE135 is also a potent ...		Retinoid Receptor
TN1927	Methyl Kakuol	1-(6-methoxy-1,3-benzodioxol-5-yl)propan-1-one	TRP/TRPV Channel
	Methyl Kakuol is an agonist of TRPA1 with an EC50 of 0.27 µM and can be used in studies about acting as an active ingredient in MBST constituent Asiasari Radix.		TRP/TRPV Channel