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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T36100 | K-TMZ | ||
K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lin... | |||
T1178 | Temozolomide | NSC 362856,TZM,CCRG 81045,TMZ | Apoptosis , DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy |
Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy. | |||
T4517 | L189 | DNA , DNA/RNA Synthesis | |
L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM). | |||
T21463 | Temozolomide Acid | TMZA | Others |
Temozolomide Acid (TMZA) is a metabolite of temozolomide (TMZ). Temozolomide processes anticancer activity in vitro. Temozolomide (TMZ) is an oral alkylating agent used to treat glioblastoma multiforme (GBM) and astrocyt... | |||
T35688 | MTIC | NSC 407347 | Drug Metabolite |
MTIC is the active metabolite of Temozolomide (TMZ) with anticancer and antitumor activity and is used in the study of melanoma.3'-Sialyllactose (3'-SL) sodium is a prebiotic with anti-inflammatory activity. | |||
T61694 | PARP1-IN-10 | ||
PARP1-IN-10 (compound 12c) is a highly potent and non-cytotoxic PARP1 inhibitor, displaying an in vitro IC50 value of 50.62 nM. This compound effectively induces cell cycle arrest at the G2/M phase and apoptosis, while a... | |||
T68663 | GPI-15427 | ||
GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiform... |