tmprss2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5092	AIM-100	AIM100	ACK
	AIM-100 is a Ack1 inhibitor (IC50: 24 nM).		ACK
T0828	Bromhexine hydrochloride	Bromhexine HCl,Auxit,Bisolvon	SARS-CoV , HIV Protease , Autophagy
	Bromhexine hydrochloride (Bisolvon) is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.		SARS-CoV , HIV Protease , Autophagy
T2391	Camostat mesylate	FOY-S980,FOY305,Camostat mesilate	Serine/threonin kinase , SARS-CoV , Sodium Channel
	Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.		Serine/threonin kinase , SARS-CoV , Sodium Channel
T0860L	Mefloquine	Ro215998,WR 142490,Ro-215998,Lariam,Ro 215998	Others
	Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic l...		Others
T74040	Boc-Gln-Ala-Arg-AMC hydrochloride
	Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorescent compound that serves as a substrate for trypsin and is also used to determine the protein hydrolysis activity of TMPRSS2.
T60085	MM3122	GTPL11533,MM-3122,Ac-GQFR-kbt	SARS-CoV
	MM3122 (MM-3122) is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.		SARS-CoV
T29110	VPC-13163	2,3-dihydro-2,3'-Bi-1H-indole,VPC13163,NSC52361,NSC 52361,VPC 13163	Others
	VPC-13163 (NSC-52361) has strong anti-proliferative activity against LNCaP and Enzalutamide-resistant prostate cancer cell lines (MR49F) whereas it did not affect the growth of AR independent PC3 cell line. It also inhib...		Others
T3712	Mivebresib	ABBV-075	Apoptosis , Epigenetic Reader Domain
	Mivebresib (ABBV-075), also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration, the bromodomain inhibitor ABBV-075 binds to the...		Apoptosis , Epigenetic Reader Domain
T71079	I 432
	I 432 is a TMPRSS2 (transmembrane serine proteinase 2) inhibitor (Ki =0.9 nM).
T78402	Boc-Gln-Ala-Arg-AMC acetate
	Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate primarily used for assaying trypsin activity and additionally suitable for evaluating the proteolytic function of TMPRSS2[1][2].
T78610	Propamidine		Parasite
	Propamidine acts as a covalent inhibitor of TMPRSS2 and exhibits antibacterial properties. [1]		Parasite
T79920	Debrisoquin	Debrisoquine,Ro 5-3307/1,Isocaramidine	SARS-CoV
	Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitor that prevents SARS-CoV-2 from entering human lung cells through TMPRSS2-dependent pathways, exhibiting an IC50 value of 22μM. It holds potential for use in antiviral res...		SARS-CoV
T81205	SARS-CoV-2-IN-66		SARS-CoV
	SARS-CoV-2-IN-66 (1), a derivative of vitamin K, functions as an inhibitor of SARS-CoV-2, exhibiting an effective concentration (EC50) of 70.8 μM in VeroE6/TMPRSS2 cells [1].		SARS-CoV
T81204	SARS-CoV-2-IN-67		SARS-CoV
	SARS-CoV-2-IN-67 (Compound 16), a derivative of vitamin K, exhibits anti-SARS-CoV-2 properties, with an effective concentration (EC50) of 64.8 μM in VeroE6/TMPRSS2 cells, and inhibits SARS-CoV-2 RdRp activity [1].		SARS-CoV
T69035	Camostat free base
	Camostat, also known as FOY 305, is a serine protease inhibitor. Camostat is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or...
T81849	MAT-POS-e194df51-1		SARS-CoV
	MAT-POS-e194df51-1 is an orally active, non-covalent, non-peptide inhibitor of the SARS-CoV-2 main protease (M^pro) with an IC_50 of 37nM. It exhibits cytotoxicity, with EC_50 values of 64nM in A549-ACE2-TMPRSS2 cells an...		SARS-CoV
T81206	SARS-CoV-2-IN-65		SARS-CoV
	SARS-CoV-2-IN-65 (compound 2f (81)) is a potent, orally active reversible inhibitor of SARS-CoV-2 entry, primarily obstructing the RBD:ACE2 interaction and TMPRSS2 activity within the ACE2-dependent pathway in Calu-3 cel...		SARS-CoV