tlr7-in-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T38078	TLR7/8-IN-1	TLR7/8-IN-1	TLR
	TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research[1].		TLR
T39669	TLR7/8/9-IN-1	TLR7/8/9-IN-1	TLR
	TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.		TLR
T4258	TLR7 agonist 2	TLR7-agonist-1,TLR7-IN-1	TLR
	TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).		TLR
T9645	CU-115	N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide	TLR
	CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-α and IL-1β activated by R-848 in THP-1 cells.		TLR
T6964	Resiquimod	R848,S28463	HCV Protease , TLR
	Resiquimod (R848) is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and acti...		HCV Protease , TLR
T79068	TLR7/8 agonist 8
	TLR7/8 agonist 8 (compound 24m) is a potent dual agonist for toll-like receptors 7 and 8 (TLR7/8), exhibiting half-maximal effective concentrations (EC50s) of 27 nM for human TLR7 (hTLR7) and 12 nM for human TLR8 (hTLR8)...
T61601	TLR7/8 antagonist 2
	TLR7/8 antagonist 2 (Compound 15) is a highly potent and orally active agonist of TLR7/8, exhibiting IC50 values of 4.9 and 0.6 nM for TLR7 and TLR8, respectively. Its strong affinity for these receptors makes it a promi...
T62178	TLR7/8 antagonist 1
	TLR7/8 Antagonist 1 (Compound 16c), an imidazoquinoline derivative, is a potent TLR7/8 agonist with IC50 values of 3.91 and 2.19 μM for TLR7 and TLR8, respectively. rel-O-2050 (TLR-2050) is a key target for drug developm...
T74870	TMX-201
	TMX-201, a TLR7 ligand-phospholipid conjugate, exhibits potent immune-stimulatory activity and is utilized in breast cancer and melanoma research [1].
T74872	ODN 105870
	ODN 105870, a G-modified inhibitory oligonucleotide (INH-ODN), selectively inhibits TLR7 and is utilized in the research of inflammatory immune responses [1].
T79877	MTvkPABC-P5
	MTvkPABC-P5d, functioning as a TLR7 agonist, serves as an immune stimulant and is utilized in the synthesis of immune-stimulating antibody conjugates (ISACs) [1].
T11482	GSK2245035		Others
	GSK2245035 is a highly selective intranasal TLR7 agonist with preferential Type-1 interferon (IFN)-stimulating properties (pEC50s: 9.3 and 6.5 for IFNα and TFNα). It effectively suppresses allergen-induced Th2 cytokine p...		Others
T74873	ODN 105871
	ODN 105871, a G-modified inhibitory oligonucleotide (INH-ODN), acts as a selective inhibitor of Toll-like receptor 7 (TLR7). It is utilized in the study of inflammatory immune responses [1].
T37287	Enpatoran hydrochloride
	Enpatoran (M5049) hydrochloride is a potent and orally active dual inhibitor of TLR7/8 with IC50 values of 11.1 nM and 24.1 nM in HEK293 cells, respectively. This compound specifically inhibits TLR7 and TLR8, while showi...
T73963	Hydroxychloroquine Impurity E
	Hydroxychloroquine Impurity E, an impurity found in Hydroxychloroquine, a synthetic antimalarial compound that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling, has been shown to effectively inhibit SARS-CoV-2 inf...
T14035	3M-011		TLR
	3M-011, a potent dual toll-like receptor TLR7/8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibit...		TLR
T73964	Hydroxychloroquine Impurity F
	Hydroxychloroquine Impurity F, an impurity in Hydroxychloroquine, is identified in the synthetic antimalarial agent known for its capability to inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Additionally, Hydroxychlo...
T74348	HE-S2		PD-1/PD-L1
	HE-S2, an antibody-drug conjugate, elicits a potent antitumor immune response by inhibiting the PD-1/PD-L1 interaction and stimulating the Toll-like receptor 7/8 (TLR7/8) signaling pathway, resulting in significant antit...		PD-1/PD-L1
T79069	TLR7/8 agonist 9
	TLR7/8 agonist 9 (Compound 25a), exhibiting EC50 values of 40 nM and 23 nM for hTLR7 and hTLR8 respectively, demonstrates anti-tumor properties and enhances the efficacy of PD-1/PD-L1 blockade treatments. This compound i...
T22091	Imiquimod hydrochloride
	Imiquimod hydrochloride (R 837 hydrochloride), a selective toll-like receptor 7 (TLR7) agonist, functions as an immune response modifier with in vivo antiviral and antitumor properties. It is utilized in researching exte...