Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK2245035 is a highly selective intranasal TLR7 agonist with preferential Type-1 interferon (IFN)-stimulating properties (pEC50s: 9.3 and 6.5 for IFNα and TFNα). It effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 8-10 weeks | $ 272.00 | |
25 mg | 8-10 weeks | $ 947.00 | |
50 mg | 8-10 weeks | $ 1,230.00 | |
100 mg | 8-10 weeks | $ 1,640.00 | |
1 mL * 10 mM (in DMSO) | 8-10 weeks | $ 298.00 |
Description | GSK2245035 is a highly selective intranasal TLR7 agonist with preferential Type-1 interferon (IFN)-stimulating properties (pEC50s: 9.3 and 6.5 for IFNα and TFNα). It effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. |
Targets&IC50 | TNF-α:6.5(pEC50), IFN-α:9.3(pEC50) |
In vitro | In a dose-dependent manner,GSK2245035 (0.01, 0.1, 1, 10, 100, 1000, 10000 nM;?6 days) reduces levels of the Th2 cytokines IL-5 and IL-13 released in response to Timothy grass or house dust mite in human PBMC cultures derived from individuals allergic to these allergens. |
In vivo | GSK2245035 (3, 30, 300, 3000 ng/kg; 6 hours) treatment can make plasma IP-10 provided the most sensitive biomarker of target engagement with raised levels of this chemokine detected at doses of 30 ng/kg and above in the cynomolgus monkey.?GSK2245035 (i.n.; 0.03-1 mg/kg; 6 hours) makes dose-related increasing in IFNα levels in serum at doses of 0.3 mg/kg and above at the 2 h time point which had subsided at 6 h. |
Molecular Weight | 390.52 |
Formula | C20H34N6O2 |
CAS No. | 1207629-49-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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GSK2245035 1207629-49-9 Others GSK-2245035 GSK 2245035 inhibitor inhibit