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TLR7 agonist 2

Catalog No. T4258 CAS 1642857-69-9

Synonyms: TLR7-agonist-1, TLR7-IN-1

TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).

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TLR7 agonist 2, CAS 1642857-69-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 159.00
2 mg	In stock	$ 253.00
5 mg	In stock	$ 522.00
10 mg	In stock	$ 755.00
25 mg	In stock	$ 1,170.00
50 mg	In stock	$ 1,580.00
100 mg	In stock	$ 2,130.00
1 mL * 10 mM (in DMSO)	In stock	$ 385.00

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Purity: 98.98%

Biological Description

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Storage & Solubility Information

Description	TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
Targets&IC50	TLR7:LEC: 0.4 μM
In vitro	In HEK293 cell, Receptor 7 (TLR7) agonist with a lowest effective concentration (LEC) of 0.4 μM. For human TLR8,LEC of TLR7-agonist-1 is >100 μM. For the hERG potassium ion channel 3H-dofetilide,TLR7-agonist-1 has limited inhibition of binding (IC50 >50 μM).
Cell Research	The ability of TLR7-agonist-1 to activate human TLR7 and/or TLR8 is assessed by using HEK293 cells. Briefly, HEK293 cells are grown in culture medium (DMEM supplemented with 10% FCS and 2 mM Glutamine). Transfected cells are then detached with Trypsin-EDTA, washed in PBS and resuspended in medium to a density of 1.67×105 cells/mL. Thirty microliters of cells are then dispensed into each well in 384-well plates, where 10 μL of TLR7-agonist-1 in 4% DMSO is already present. Following 6 hours incubation at 37°C, 5% CO2, the luciferase activity is determined by adding 15 μL of Steady Lite Plus substrate to each well and readout performed on a microplate imager. Lowest effective concentrations (LEC) values are determined for TLR7-agonist-1.
Animal Research	In C57Bl/6 mice model,Single oral administration of 0.3, 1, 3, and 10 mg/kg doses of TLR7-agonist-1.

Synonyms	TLR7-agonist-1, TLR7-IN-1
Molecular Weight	336.35
Formula	C17H16N6O2
CAS No.	1642857-69-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 160 mg/mL

References and Literature

1. McGowan DC, et al. Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B. J Med Chem. 2017 Jul 27;60(14):6137-6151.

Citations

1. Lu J, Zhong X, Guo C, et al.TLR7-MyD88-DC-CXCL16 axis results neutrophil activation to elicit inflammatory response in pustular psoriasis.Cell Death & Disease.2023, 14(5): 1-13.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max Immuno-Oncology Compound Library NO PAINS Compound Library HIF-1 Signaling Pathway Compound Library Pyroptosis Compound Library Target-Focused Phenotypic Screening Library Nonsteroidal Anti-Inflammatory Compound Library Immunology/Inflammation Compound Library

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Related compounds with same targets

Vesatolimod Hydroxychloroquine TLR7/8-IN-1 AXC-715 trihydrochloride SM-276001 CU-T12-9 Atractylenolide I MD2-IN-1

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Keywords

TLR7 agonist 2 1642857-69-9 Immunology/Inflammation TLR inhibit TLR7-agonist-1 TLR-7 agonist 2 Inhibitor TLR7-IN-1 Toll-like Receptor (TLR) inhibitor

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