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Search Results for " smad2 "

10

Compounds

Cat No. Product Name Synonyms Targets
T5247 Trimethylamine N-oxide dihydrate TMANO Dihydrate Others , Endogenous Metabolite
Trimethylamine N-oxide dihydrate (TMANO Dihydrate), a product of the oxidation of trimethylamine, is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays.
T2123 LY2109761 Autophagy , TGF-beta/Smad
LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2.
T3876 Loureirin B PAI-1 , ERK , Potassium Channel , JNK
Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathw...
T3636 (E)-SIS3 SIS3,SIS3 HCl TGF-beta/Smad
(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblas...
T80628 Myristoyl tetrapeptide-12 TGF-beta/Smad
Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].
T10426 AZ12601011 ALK
AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively targeting ALK4, TGFBR1, and ALK7, AZ12601011 effectively in...
T77076 Luspatercept
Luspatercept (ACE-536), a recombinant modified ActRIIB fusion protein, selectively binds to transforming growth factor β superfamily ligands, thereby enhancing erythrocyte production and advancing the maturation of eryth...
T61203 ALK5-IN-8
ALK5-IN-8 is a highly effective inhibitor of TGFβRI (ALK5). It hinders the phosphorylation of ALK5 on downstream signaling proteins (Smad2 or Smad3) by obstructing the interaction between TGFβRI and ligands. Consequently...
T61029 TP0427736 hydrochloride
TP0427736 hydrochloride can be used in the androgenic alopecia (AGA) research. TP0427736 hydrochloride inhibits the phosphorylation of Smad2/3 in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydr...
T26925 Butaprost Butaprostum,TR-4979,(R)-Butaprost
Butaprost is a chemical compound that functions as a selective agonist for the prostaglandin E receptor (EP2). It exhibits an EC50 of 33 nM and a Ki of 2.4 μM when interacting with the murine EP2 receptor. However, Butap...
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