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Cat No. | Product Name | Synonyms | Targets |
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T12935 | SMN-C3 | MV8T2MCK57 | DNA/RNA Synthesis |
SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA). | |||
T73475 | SMN-C2 | DNA/RNA Synthesis | |
SMN-C2 is a selective regulator of SMN2 gene splicing, a risdiplam analogue, a selective RNA-binding ligand that regulates pre-mRNA splicing and acts by binding to SMN2 pre-mRNA.SMN-C2 has the potential to be used in the... | |||
T4641 | Branaplam | LMI 070,NVS-SM1 | Others , Potassium Channel , DNA/RNA Synthesis |
Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. | |||
T34664 | SMN2-Stablizer-27 | SMN2-Stablizer 27,SMN2 Stablizer-27 | |
SMN2-Stablizer-27 is a stablizer of survival of motor neuron 2 (SMN2), and a post-translationally stablizing SMN protein for the treatment of spinal muscular atrophy (SMA). | |||
T16902 | SMND-309 | Others | |
SMND-309 is a metabolite of salvianolic acid B. It also shows neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats. | |||
T16757 | Risdiplam | RO7034067,RG7916 | DNA/RNA Synthesis |
Risdiplam (RO7034067) (RG7916) is orally administered. Risdiplam is a centrally and peripherally distributed SMN2 pre-mRNA splicing modifier which increases survival motor neuron (SMN) protein levels[1]. | |||
T3336 | Rg3039 | PF-06687859 | Others |
Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an... | |||
T33764 | NVS-SM2 | ||
NVS-SM2 is an effective small molecule splicing enhancer of SMN2 with oral activity. NVS-SM2 showed increased exon 7 inclusion and upregulated SMN protein expression in SMA fibroblasts and SMN cells Δ7 5025 mouse myoblas... | |||
T62381 | Branaplam hydrochloride | ||
Branaplam (LMI070; NVS-SM1) hydrochloride is a selective, orally active SMN2 splicing modulator that acts on SMN (EC50: 20 nM). branaplam hydrochloride inhibits hERG (IC50: 6.3 μM). In a mouse model of severe spinal musc... | |||
T64288 | RG7800 hydrochloride | ||
RG7800 hydrochloride is an orally active SMN2 splicing modulator that acts on SMN2 splicing (EC1.5x: 23 nM) and SMN proteins (EC1.5x: 87 nM). | |||
T35594 | Cuspin-1 | ||
The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative dise... | |||
T28067 | ML372 | ML 372,ML-372 | |
ML372 is a potent and selective SMN Modulator (EC50 = 12 nM, 325% increase inSMN2) with good potency, pharmacokinetics, tolerance, and CNS penetration. | |||
T26893 | Branaplam mesylate (1562338-42-4 free base) | LMI070,Branaplam mesylate,LMI 070,LMI-070 | |
Branaplam is a highly potent, selective and orally active SMN2 splicing modulator. Branaplam increases the amount of functional SMN protein produced by the SMN2 gene through modifying its splicing. | |||
T38656 | Nusinersen | ||
Nusinersen, an antisense oligonucleotide drug, modifies the pre-messenger RNA (pre-mRNA) splicing of the SMN2 gene, thereby enhancing the production of the full-length Survival Motor Neuron (SMN) protein. | |||
T78046 | RG7800 tetrahydrochloride | RO6885247 tetrahydrochloride | DNA/RNA Synthesis |
RG7800 hydrochloride is an orally active modulator of SMN2 splicing, exhibiting EC50 values of 23 nM for SMN2 splicing and 87 nM for SMN protein production. This compound holds promise as a therapeutic agent for spinal m... | |||
T12718 | RG7800 hydrochloride (1449598-06-4 free base) | RO6885247 hydrochloride,RG7800 hydrochloride | Others |
RG7800 hydrochloride is an orally active modulator of SMN2 splicing. |
Cat No. | Product Name | Species | Expression System |
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TMPY-03047 | Stathmin 1 Protein, Human, Recombinant (His) | Human | E. coli |
Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in GC and ... | |||
TMPH-02920 | SMN1 Protein, Mouse, Recombinant (His & Myc) | Mouse | HEK293 Cells |
SMN1 Protein, Mouse, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 35.3 kDa and the accession number is P97801. | |||
TMPY-03456 | SRFBP1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
SRFBP1 contains 7 WD repeats and belongs to the WD repeat STRAP family. SRFBP1 may play a role in the cellular distribution of the SMN complex. The SMN complex plays an essential role in spliceosomal snRNP assembly in th... | |||
TMPH-02229 | TRA2B Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor ne... | |||
TMPH-02228 | TRA2B Protein, Human, Recombinant (His & Myc) | Human | Baculovirus Insect Cells |
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor ne... |