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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11285 | FIDAS-5 | Others | |
FIDAS-5, a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM, competitively inhibits S-adenosylmethionine (SAM) binding to MAT2A. It exhibits anticancer activities. | |||
T11284 | FIDAS-3 | Others , Wnt/beta-catenin , Methionine Adenosyltransferase (MAT) | |
FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by effectively competing with S-adenosylmethionine (SAM) for ... | |||
T14141 | AGI-24512 | Others , Methionine Adenosyltransferase (MAT) | |
AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in vitro. | |||
T4676 | Sardomozide dihydrochloride | CGP 48664 dihydrochloride,Sardomozide dihydrochloride | Others |
Sardomozide dihydrochloride (CGP 48664 dihydrochloride) is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC, IC50 = 5 nM). | |||
T8227 | 5'-Methylthioadenosine | Methylthioadenosine,5'-(Methylthio)-5'-deoxyadenosine,5'-Deoxy-5'-(methylthio)adenosine,5'-S-Methyl-5'-thioadenosine | Endogenous Metabolite |
5'-Methylthioadenosine (Methylthioadenosine) is produced from S-adenosylmethionine and behaves as a powful inhibitory product. | |||
T64377 | AGI-41998 tautomers | Others | |
AGI-41998 tautomers is a tautomerism of pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-. pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-... | |||
T12908 | SIBA | 5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine | Nucleoside Antimetabolite/Analog , HSV |
SIBA (5'-Deoxy-5'-isobutylthioadenosine) is a synthetic analogue of SAH, acts as an inhibitor of S-adenosylmethionine-mediated transmethylation. SIBA can interfere with a variety of enzymatic activities in vitro, such as... | |||
T26177 | S-Aristeromycinylhomocysteine | S-Aristeromycinyl-L-homocysteine | |
S-Aristeromycinylhomocysteine is an inhibitor of adenosylmethionine decarboxylase. | |||
T69891 | CGP 40215 | ||
CGP 40215 is a specific S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor that was found to inhibit the growth of Leishmania donovani promastigotes | |||
T12833 | Sardomozide | CGP 48664,SAM-486A | Others |
Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC)(IC50 of 5 nM). | |||
T29651 | Ademetionine, (S)- | ||
Ademetionine (S-adenosylmethionine; SAMe) is a ubiquitous metabolite present in all cells and biological fluids, and serves as a methyl donor in a multitude of different methylation reactions involving proteins, phosphol... | |||
T35764 | S-Farnesyl Thioacetic Acid | ||
S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine which behaves as a competitive inhibitor of isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). It can ... | |||
T37693 | N-acetyl-S-geranylgeranyl-L-Cysteine | ||
N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate f... | |||
T35413 | (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride) | ||
(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. Its metabolites participate in... | |||
T71162 | MDL-73811 | ||
MDL-73811 is a potent AdoMetDC (S-adenosylmethionine decarboxylease) inhibitor and anti-trypanosomal compound that cures Brucella infections in mice. However despite the good activity of MDL 73811, rapid plasma clearance... | |||
T9730 | AGI-41998 | ||
AGI-41998 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A) that penetrates the blood-brain barrier.AGI-41998 inhibits s-adenosylmethionine (SAM) metabolizing enzymes and methionine adenosyltransferase 2... | |||
T79414 | SARS-CoV-2-IN-60 | SARS-CoV | |
SARS-CoV-2-IN-60 (compound 5a) is a specific, irreversible inhibitor of SARS-CoV-2 nsp16-nsp10 methyltransferase, competing with S-adenosylmethionine (SAM) and exhibiting an IC50 of 9 µM and a Ki of 26 µM. It binds to a ... |