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Search Results for " s-adenosylmethionine "

17

Compounds

Cat No. Product Name Synonyms Targets
T11285 FIDAS-5 Others
FIDAS-5, a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM, competitively inhibits S-adenosylmethionine (SAM) binding to MAT2A. It exhibits anticancer activities.
T11284 FIDAS-3 Others , Wnt/beta-catenin , Methionine Adenosyltransferase (MAT)
FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by effectively competing with S-adenosylmethionine (SAM) for ...
T14141 AGI-24512 Others , Methionine Adenosyltransferase (MAT)
AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in vitro.
T4676 Sardomozide dihydrochloride CGP 48664 dihydrochloride,Sardomozide dihydrochloride Others
Sardomozide dihydrochloride (CGP 48664 dihydrochloride) is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC, IC50 = 5 nM).
T8227 5'-Methylthioadenosine Methylthioadenosine,5'-(Methylthio)-5'-deoxyadenosine,5'-Deoxy-5'-(methylthio)adenosine,5'-S-Methyl-5'-thioadenosine Endogenous Metabolite
5'-Methylthioadenosine (Methylthioadenosine) is produced from S-adenosylmethionine and behaves as a powful inhibitory product.
T64377 AGI-41998 tautomers Others
AGI-41998 tautomers is a tautomerism of pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-. pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-...
T12908 SIBA 5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine Nucleoside Antimetabolite/Analog , HSV
SIBA (5'-Deoxy-5'-isobutylthioadenosine) is a synthetic analogue of SAH, acts as an inhibitor of S-adenosylmethionine-mediated transmethylation. SIBA can interfere with a variety of enzymatic activities in vitro, such as...
T26177 S-Aristeromycinylhomocysteine S-Aristeromycinyl-L-homocysteine
S-Aristeromycinylhomocysteine is an inhibitor of adenosylmethionine decarboxylase.
T69891 CGP 40215
CGP 40215 is a specific S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor that was found to inhibit the growth of Leishmania donovani promastigotes
T12833 Sardomozide CGP 48664,SAM-486A Others
Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC)(IC50 of 5 nM).
T29651 Ademetionine, (S)-
Ademetionine (S-adenosylmethionine; SAMe) is a ubiquitous metabolite present in all cells and biological fluids, and serves as a methyl donor in a multitude of different methylation reactions involving proteins, phosphol...
T35764 S-Farnesyl Thioacetic Acid
S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine which behaves as a competitive inhibitor of isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). It can ...
T37693 N-acetyl-S-geranylgeranyl-L-Cysteine
N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate f...
T35413 (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)
(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. Its metabolites participate in...
T71162 MDL-73811
MDL-73811 is a potent AdoMetDC (S-adenosylmethionine decarboxylease) inhibitor and anti-trypanosomal compound that cures Brucella infections in mice. However despite the good activity of MDL 73811, rapid plasma clearance...
T9730 AGI-41998
AGI-41998 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A) that penetrates the blood-brain barrier.AGI-41998 inhibits s-adenosylmethionine (SAM) metabolizing enzymes and methionine adenosyltransferase 2...
T79414 SARS-CoV-2-IN-60 SARS-CoV
SARS-CoV-2-IN-60 (compound 5a) is a specific, irreversible inhibitor of SARS-CoV-2 nsp16-nsp10 methyltransferase, competing with S-adenosylmethionine (SAM) and exhibiting an IC50 of 9 µM and a Ki of 26 µM. It binds to a ...
TargetMol