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Ademetionine, (S)-

Catalog No. T29651 CAS 78548-84-2

Ademetionine (S-adenosylmethionine; SAMe) is a ubiquitous metabolite present in all cells and biological fluids, and serves as a methyl donor in a multitude of different methylation reactions involving proteins, phospholipids, catecholamines and DNA.

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Ademetionine, (S)-, CAS 78548-84-2

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	398.44
Formula	C15H22N6O5S
CAS No.	78548-84-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lane DJR, Bae DH, Siafakas AR, Rahmanto YS, Al-Akra L, Jansson PJ, Casero RA Jr, Richardson DR. Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes. Biochim Biophys Acta. 2018 May 16. pii: S0925-4439(18)30177-7. doi: 10.1016/j.bbadis.2018.05.007. [Epub ahead of print] PubMed PMID: 29777905. 2. Lhuissier E, Aury-Landas J, Bouet V, Bazille C, Repesse Y, Freret T, Boumédiene K, Baugé C. Evaluation of the impact of S-adenosylmethionine-dependent methyltransferase inhibitor, 3-deazaneplanocin A, on tissue injury and cognitive function in mice. Oncotarget. 2018 Apr 17;9(29):20698-20708. doi: 10.18632/oncotarget.25062. eCollection 2018 Apr 17. PubMed PMID: 29755682; PubMed Central PMCID: PMC5945538. 3. Sadek KM, Lebda MA, Nasr NE, Nasr SM, El-Sayed Y. Role of lncRNAs as prognostic markers of hepatic cancer and potential therapeutic targeting by S-adenosylmethionine via inhibiting PI3K/Akt signaling pathways. Environ Sci Pollut Res Int. 2018 May 10. doi: 10.1007/s11356-018-2179-8. [Epub ahead of print] PubMed PMID: 29748795. 4. Liu T, Yang H, Fan W, Tu J, Li TWH, Wang J, Shen H, Yang J, Xiong T, Steggerda J, Liu Z, Noureddin M, Maldonado SS, Annamalai A, Seki E, Mato JM, Lu SC. Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. Gastroenterology. 2018 May 4. pii: S0016-5085(18)34482-2. doi: 10.1053/j.gastro.2018.04.032. [Epub ahead of print] PubMed PMID: 29733835.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ademetionine, (S)- 78548-84-2 Ademetionine, (S) Ademetionine, inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.