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Sardomozide

Catalog No. T12833 CAS 149400-88-4

Synonyms: CGP 48664, SAM-486A

Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC)(IC50 of 5 nM).

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Sardomozide, CAS 149400-88-4

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,520.00
50 mg	8-10 weeks	$ 1,980.00
100 mg	8-10 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC)(IC50 of 5 nM).
Targets&IC50	SAMDC:5 nM
In vitro	Sardomozide acts as an inhibitor of S-adenosylmethionine decarboxylase (SAMDC), showing potency with an IC50 value of 5 nM in cell assays. With a 48-hour exposure to 3 μM of Sardomozide, the activity of intracellular SAMDC is diminished to 10% compared to the control[1]. Additionally, in cells grown in the presence of Sardomozide, specifically CHO/664 cells treated with DENSPM, there is an absence of vacuole formation. These cells also exhibit inhibited growth and maintain DENSPM levels comparable to those in parental CHO cells[2].

Synonyms	CGP 48664, SAM-486A
Molecular Weight	230.27
Formula	C11H14N6
CAS No.	149400-88-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54(12):3210-7. 2. Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58(17):3883-90.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Sardomozide 149400-88-4 Others CGP-48664 CGP48664 CGP 48664 SAM-486A inhibitor inhibit

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