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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2087 | AF-353 | Ro-4 | P2X Receptor |
AF-353 (Ro-4), an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0). | |||
T22416 | RO495 | CS-2667 | Tyrosine Kinases , JAK |
RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays | |||
T5412 | RO4987655 | CH4987655,RG7167 | MEK |
RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2). | |||
T6274 | RO4929097 | RG-4733 | Beta Amyloid , Gamma-secretase |
RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM). | |||
T83495 | [D-Pro4,D-Trp7,9] Substance P (4-11) | ||
[D-Pro4,D-Trp7,9] Substance P (4-11) acts as a potent antagonist to Substance P, significantly reducing plasma aldosterone (ALDO) concentrations[1]. | |||
T83496 | [D-Pro4,D-Trp7,9,10] Substance P (4-11) | ||
[D-Pro4,D-Trp7,9,10] Substance P (4-11) serves as a potent antagonist of the tachykinin family of neuropeptides [1]. | |||
T76406 | [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) | ||
[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist that effectively inhibits the actions of gold-protein-substance P (GPSP) and substance P (SP), demonstrating its efficacy in neutralizing t... | |||
T28600 | Ro4491533 | Ro 4491533,Ro-4491533 | |
Ro4491533 is a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3). | |||
T28601 | RO4988546 | RO-4988546,RO 4988546 | |
RO4988546 is a potent negative allosteric modulator of mGlu₂/₃. | |||
T68623 | RO4583298 | ||
RO4583298 is a highly potent dual NK1/NK3 receptor antagonist with in vivo activity. | |||
T68459 | RO4927350 | ||
RO4927350 is a potent and highly selective non-ATP-competitive MEK1/2 inhibitor. RO4927350 selectively blocks the MAPK pathway signaling both in vitro and in vivo, which results in significant antitumor efficacy in a bro... |