rt6 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0097	MRT67307	MRT67307 HCl	IκB/IKK , Autophagy
	Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophage...		IκB/IKK , Autophagy
T5356	MRT68921 HCl		Autophagy
	MRT68921 hydrochloride is a potent inhibitor of both ULK1 and ULK2 (IC50s: 2.9 and 1.1 nM, respectively).		Autophagy
T24793	SIRT6-IN-5	SIRT6 inhibitor5,SIRT6 IN 5,SIRT6 inhibitor-5,SIRT6 inhibitor 5	Sirtuin
	SIRT6-IN-5（SIRT6 inhibitor 5） is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.SIRT6-IN-5 is immunosuppressive and chemo-sensitizing, increases H3K9 acetylation and glucose uptake in cultured cells, ...		Sirtuin
T5162	MRT67307 HCl (1190378-57-4(free base))		IκB/IKK , AMPK , Autophagy
	MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).		IκB/IKK , AMPK , Autophagy
T6899	MRT68921	MRT68921 HCl	Autophagy
	MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.		Autophagy
T9142	MRT68921 dihydrochloride		Autophagy
	MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).		Autophagy
T28784	SIRT6-IN-1
	SIRT6-IN-1, a novel SIRT6 inhibitor, reduces glycemia and improves oral glucose tolerance in unfed wild-type mice.
T62186	ART615
	ART615 is a related isomer of ART558. ART615 inhibits Polθ by <10% at 12 μM and is able to act as a control for ART558 (IC50:7.9 nM).
T23028	MRT67307 HCl (1190378-57-4 free base)	MRT67307 HCl	Others
	MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it i...		Others
T72484	SIRT6 activator 12q
	SIRT6 activator 12q is a potent, selective, and orally active compound that activates SIRT6. It demonstrates IC50 values of 171.20 μM for SIRT1, >200 μM for SIRT2, SIRT3, and SIRT5, and 0.58 μM for SIRT6, indicating its ...
T79689	SIRT6-IN-3		Sirtuin
	SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts apoptosis. It enhances the responsiveness of cancer cells to ...		Sirtuin

Compounds

MRT67307

T0097

Synonym: MRT67307 HCl

Target: IκB/IKK, Autophagy

Synonym: SIRT6 inhibitor5,SIRT6 IN 5,SIRT6 inhibitor-5,SIRT6 inhibitor 5

Target: Sirtuin

MRT67307 HCl (1190378-57-4(free base))

T5162

Synonym:

Target: IκB/IKK, AMPK, Autophagy

MRT68921

T6899

Synonym: MRT68921 HCl

Target: Autophagy

MRT68921 dihydrochloride

MRT67307 HCl (1190378-57-4 free base)

T23028

Synonym: MRT67307 HCl

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-06532	ART1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	ART1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.55 kDa and the accession number is NP_004305.2.
TMPH-01742	SIRT6 Protein, Human, Recombinant (GST)	Human	E. coli
	SIRT6 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 66.0 kDa and the accession number is Q8N6T7.

ART1 Protein, Human, Recombinant (His)

TMPY-06532

Species: Human

Expression System: HEK293 Cells

SIRT6 Protein, Human, Recombinant (GST)

TMPH-01742

Species: Human

Expression System: E. coli

Search Result

Targets

Compounds

Recombinant Proteins

Compounds

Recombinant Proteins