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MRT68921 dihydrochloride

MRT68921 dihydrochloride
MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).
Catalog No. T9142Cas No. 2080306-21-2
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Purity:100%
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MRT68921 dihydrochloride

Catalog No. T9142Cas No. 2080306-21-2
MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mg$35In Stock
5 mg$56In Stock
10 mg$94In Stock
25 mg$197In Stock
50 mg$357In Stock
100 mg$467In Stock
200 mg$687In Stock
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Product Introduction

Bioactivity
Description
MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).
Targets&IC50
ULK2:1.1 nM, ULK1:2.9 nM
In vitro
MRT68921 inhibits ULK1 and ULK2 in vitro and block autophagy in cells.?MRT68921 is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC50 for ULK1 (2.9 nm) and greater than a 30-fold reduction for ULK2 (1.1 nm).?Autophagy-inhibiting capacity of the compounds is specifically through ULK1.?ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation[1]
Chemical Properties
Molecular Weight507.499
FormulaC25H36Cl2N6O
Cas No.2080306-21-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 33.33 mg/mL (65.67 mM), Sonication is recommended.
DMSO: 2 mg/mL (3.94 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM1.9704 mL9.8522 mL19.7045 mL98.5224 mL
H2O
1mg5mg10mg50mg
5 mM0.3941 mL1.9704 mL3.9409 mL19.7045 mL
10 mM0.1970 mL0.9852 mL1.9704 mL9.8522 mL
20 mM0.0985 mL0.4926 mL0.9852 mL4.9261 mL
50 mM0.0394 mL0.1970 mL0.3941 mL1.9704 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

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