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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T38421 | PRMT1-IN-1 | PRMT1-IN-1 | |
PRMT1-IN-1 is a PRMT1 inhibitor. | |||
T27133 | DCLX069 | DCLX 069,DCLX-069 | Histone Methyltransferase |
DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 occupies the SAM binding pocket to exert the inhibitory effect. DCLX069 effectively blocks cell proliferation in breast cancer, liver cancer and acute myeloid le... | |||
T2352 | AMI-1 | Histone Methyltransferase | |
AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1). | |||
T7697 | BIX-01294 | Histone Methyltransferase , Autophagy | |
BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM). | |||
T1959 | BIX-01294 trihydrochloride | BIX 01294 | Histone Methyltransferase , Autophagy |
BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase. | |||
T2097 | C-7280948 | C7280948 | Histone Methyltransferase |
C-7280948 is a PRMT1 inhibitor. | |||
T21826 | TC-E 5003 | NSC 30176 | Histone Methyltransferase |
TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM. | |||
T11500L | GSK3368715 dihydrochloride | EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl | Histone Methyltransferase |
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active and potent inhibitor of type I protein arginine methyltransferases (PRMTs) with anticancer and antitumor activity, inhibiting PRMT1, PRMT3, PRMT4... | |||
T6900 | MS023 | Histone Methyltransferase | |
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively. | |||
T10682L | CARM1-IN-1 | CARM1-IN-7G | Histone Methyltransferase |
CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM. | |||
T61338 | MS023 dihydrochloride | MS023 2HCl | Histone Methyltransferase |
MS023 dihydrochloride (MS023 2HCl) is a selective, cytosolic and highly potent inhibitor of human type I protein arginine methyltransferases (PRMTs) with antitumour activity, inhibits PRMT1, PRMT3, PRMT4, PRMT6, and PRMT... | |||
T10850 | CMP-5 | Others | |
CMP-5 is an effective and selective small-molecule inhibitor of PRMT5. CMP-5 blocks EBV-driven B lymphocyte transformation and survival, but does not show this activity against PRMT1, PRMT4 and PRMT7 enzymes. During hist... | |||
T4393 | MS049 2HCl (1502816-23-0(free base)) | Histone Methyltransferase | |
MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 μM for PRMT1, PRMT3, and PRMT8, respectively) and... | |||
T11338 | Furamidine | DB75,NSC 305831 | Others |
Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 28... | |||
T22325 | EPZ020411 hydrochloride | EPZ020411 HCl | Histone Methyltransferase |
EPZ020411 hydrochloride is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10 nM. | |||
TP2041 | C 21 | ||
Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.8 μM). Exhibits five-fold selectivity for PRMT1 over PRMT6 and >250-fold selectivity over PRMT3 and CARM1. | |||
T22342 | GSK3368715 3HCl | EPZ019997 3HCl,GSK3368715(EPZ019997) | Histone Methyltransferase |
GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM. | |||
T11500 | GSK3368715 | EPZ019997 | Histone Methyltransferase |
GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: 3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRM... | |||
T77787 | MS023 trihydrochloride | MS023 3HCl | Histone Methyltransferase |
MS023 trihydrochloride (MS023 3HCl) is a selective and potent human type I protein arginine methyltransferase (PRMT) inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer r... | |||
T15080 | DC-05 | DNA Methyltransferase , Histone Methyltransferase | |
DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively). |