nav1.7 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12181	NaV1.7 inhibitor-1		Sodium Channel
	NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).		Sodium Channel
T38911	Nav1.7-IN-8	Nav1.7-IN-8
	Nav1.7-IN-8 is a highly potent and selective inhibitor of NaV1.7, exhibiting greater selectivity for inhibiting NaV1.7 compared to the subtypes hNaV1.1 and hNaV1.5. Additionally, Nav1.7-IN-8 has inhibitory effects on CYP...
T12184	Nav1.7 inhibitor		Others
	Nav1.7 inhibitor is a potent inhibitor of Nav1.7.		Others
T12180	Nav1.7-IN-6		Others
	Nav1.7-IN-6, a selective inhibitor of Nav1.7.		Others
T28132	NaV1.7 Blocker-801
	NaV1.7 Blocker-801 is a potent NaV1.7 blocker.
T12183	Nav1.7-IN-3		Others
	Nav1.7-IN-3 is a selective and orally bioavailable inhibitor of voltage-gated sodium channel Nav1.7(IC50 of 8 nM).		Others
T12182	Nav1.7-IN-2		Others
	Nav1.7-IN-2 is avoltage-gated sodium channels (Nav) inhibitor in particular Nav 1.7(IC50 of 80 nM).		Others
T8711	PF-05186462	PF-05150122	Sodium Channel
	PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.		Sodium Channel
T2173	Veratridine		Sodium Channel
	Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.		Sodium Channel
T7502	PF 05089771 tosylate		Sodium Channel
	PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8...		Sodium Channel
T7336	ICA-121431	2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl	Sodium Channel
	ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels.		Sodium Channel
T12655	(Rac)-AMG8379	(Rac)-AMG8380	Sodium Channel
	(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.		Sodium Channel
T9685	DS-1971a		Sodium Channel
	DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.		Sodium Channel
TQ0014	GNE-131		Sodium Channel
	GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).		Sodium Channel
T17263	XEN907		Others
	XEN907 is a novel spiro oxindole NaV1.7 blocker. XEN907 also inhibits hNaV1.7 (IC50: 3 nM).		Others
T7502L	PF 05089771	PF-05089771,PF05089771	Sodium Channel
	PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent.		Sodium Channel
T15174	DSP-2230		Sodium Channel
	DSP-2230 is a selective blocker of Nav1.7/Nav1.8.		Sodium Channel
T9461	AZ194		Sodium Channel
	CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.		Sodium Channel
T62000	ABBV-318
	ABBV-318 can be used as small molecule Nav1.7/Nav1.8 blockers for the treatment of pain, with IC50 values of 2.8 μM for hNav1.7 and 3.8 μM for hNav1.8. ABBV-318 can be used to study pain-related disorders.
T23439	TC-N 1752		Sodium Channel
	TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.		Sodium Channel