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(Rac)-AMG8379

Name: (Rac)-AMG8379
Brand: TargetMol
SKU: T12655
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12655Cas No. 1641574-26-6

Alias (Rac)-AMG8380

(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379, an orally active and selective sulfonamide NaV1.7 antagonist.

(Rac)-AMG8379

🥰Excellent

Purity: 99.6%

Catalog No. T12655Alias (Rac)-AMG8380Cas No. 1641574-26-6

(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379, an orally active and selective sulfonamide NaV1.7 antagonist.

Pack Size	Price	Availability
1 mg	$195	In Stock
2 mg	$293	In Stock
5 mg	$448	In Stock
10 mg	$658	In Stock
25 mg	$987	In Stock
50 mg	$1,380	In Stock
100 mg	$1,890	In Stock
500 mg	$3,780	In Stock
1 mL x 10 mM (in DMSO)	$568	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.6%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379, an orally active and selective sulfonamide NaV1.7 antagonist.
Targets&IC50	Nav1.7 (mouse):18.6 nM (IC50), Nav1.7 (human):8.5 nM (IC50)
Synonyms	(Rac)-AMG8380

Chemical Properties

Molecular Weight	543.93
Formula	C₂₅H₁₆ClF₂N₃O₅S
Cas No.	1641574-26-6
Smiles	O=C1N(C=2C(=CC(S(NC=3C=CON3)(=O)=O)=CC2)C=C1)C4=C(OC)C=C(C(F)=C4)C5=CC(Cl)=CC(F)=C5
Relative Density.	1.527 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (91.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8385 mL	9.1924 mL	18.3847 mL	91.9236 mL
5 mM	0.3677 mL	1.8385 mL	3.6769 mL	18.3847 mL
10 mM	0.1838 mL	0.9192 mL	1.8385 mL	9.1924 mL
20 mM	0.0919 mL	0.4596 mL	0.9192 mL	4.5962 mL
50 mM	0.0368 mL	0.1838 mL	0.3677 mL	1.8385 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc