Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 148.00 | |
5 mg | In stock | $ 372.00 | |
10 mg | In stock | $ 537.00 | |
25 mg | In stock | $ 869.00 | |
50 mg | In stock | $ 1,190.00 | |
100 mg | In stock | $ 1,590.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 397.00 |
Description | GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM). |
Targets&IC50 | Nav1.7 channel:3 nM (cell free) |
In vitro | GNE-131 shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 (IC50: 0.003 μM). |
In vivo | GNE-131 shows low in vivo clearance in dog, rat, and mouse. It also displays excellent efficacy in a transgenic mouse model of induced pain. |
Molecular Weight | 442.57 |
Formula | C23H30N4O3S |
CAS No. | 1629063-81-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120 mg/mL (271.14 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GNE-131 1629063-81-5 Membrane transporter/Ion channel Sodium Channel GNE131 Na+ channels inhibit Na channels Inhibitor GNE 131 inhibitor