keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 198.00 | |
25 mg | In stock | $ 455.00 | |
50 mg | In stock | $ 672.00 | |
100 mg | In stock | $ 956.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities. |
Targets&IC50 | Nav1.4 (human):0.4 μM (IC50), Nav1.3 (human):0.3 μM (IC50), Nav1.7 (human):0.17 μM (IC50), Nav1.5 (human):1.1 μM (IC50), Nav1.8 (human):0.1 μM (IC50) |
In vitro | TC-N 1752 exhibits IC50s of 0.2, 0.1, 1.6, 0.5 and 1.4 μM for hNav1.7, hNav1.8, hNav1.9, rNav1.9, and mNav1.9[1]. TC-N 1752 state-dependently inhibits Nav1.7 channel on channels that are 20% inactivated(IC50 = 170 nM) and on fully noninactivated channels(IC50 = 3.6 μM)[1]. |
In vivo | TC-N 1752 (5 mg/ml; i.v.) attenuates Freund's adjuvant-induced sensitization of C fiber nociceptors[2]. TC-N 1752 (3-30 mg/kg; orally) exhibits analgesic effects in a dose-dependent manner in a formalin model and reduces thermal hyperalgesia produced by inflammation[3]. |
Molecular Weight | 516.52 |
Formula | C25H27F3N6O3 |
CAS No. | 1211866-85-1 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 112.5 mg/mL (217.8 mM), Sonication is recommended.
1eq. HCl: < 5.17 mg/mL
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TC-N 1752 1211866-85-1 Membrane transporter/Ion channel Sodium Channel TCN 1752 TC-N-1752 TC-N1752 TC N 1752 inhibitor inhibit