nr2b — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T25196	BZAD01	BZAD-01,BZAD 01	NMDAR
	BZAD01 is a selective NMDA NR1A/2B receptor antagonist.		NMDAR
T1186	Ifenprodil Tartrate		Potassium Channel , NMDAR , iGluR
	Ifenprodil is a selective NMDA receptor (glutamate) antagonist.		Potassium Channel , NMDAR , iGluR
T22674	Co 101244 hydrochloride	4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride	NMDAR
	Co 101244 hydrochloride (4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride) is an NR2B-containing NMDA receptor antagonist.		NMDAR
T13112L1	Tat-NR2B9c acetate	Tat-NR2B9c acetate (500992-11-0 Free base),NA-1 acetate	Others
	Tat-NR2B9c acetate (NA-1 acetate) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c acetate disrupts the PSD-...		Others
T13112	Tat-NR2B9c	Tat-NR2Bct,NA-1	NO Synthase , iGluR
	Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxi...		NO Synthase , iGluR
T81037	Tat-HA-NR2B9c
	Tat-HA-NR2B9, comprising an HIV-1 Tat transduction domain fragment, an influenza virus hemagglutinin (HA) epitope-tag, and the C-terminal 9 amino acids of NR2B (NR2B9c), has demonstrated efficacy in reducing infarct size...
T35924	Tat-NR2Baa	Tat-NR2Baa
	Tat-NR2BAA is an inactive control peptide of Tat-NR2B9c. It shares a similar sequence with Tat-NR2B9c, but possesses a double-point mutation in the COOH terminal tSXV motif. This mutation renders Tat-NR2BAA unable to bin...
T76069	Tat-NR2Baa TFA
	Tat-NR2BAA TFA serves as the inactive control peptide for Tat-NR2B9c, featuring a comparable sequence with a crucial distinction: a double-point mutation in its COOH-terminal tSXV motif. This alteration renders Tat-NR2BA...
T13112L	Tat-NR2B9c TFA	NA-1 (TFA)	Others
	Tat-NR2B9c TFA is a 20-aa peptide, and acts as an inhibitor of postsynaptic density-95 (PSD-95)(EC50 of 6.7 nM for PSD-95d2), and possesses neuroprotective efficacy.		Others
T1751	Eliprodil	SL-820715	NMDAR , iGluR
	Eliprodil (SL-820715)(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has been used in trials studying the treatment of Pa...		NMDAR , iGluR
T5385	Radiprodil	RGH-896	NMDAR , iGluR
	Radiprodil (RGH-896) (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP).		NMDAR , iGluR
T12758	Ro 25-6981		NMDAR
	Ro 25-6981 is a potent and selective activity-dependent NMDA receptors blocker containing the NR2B subunit with IC50s of 0.009 and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Ro 2...		NMDAR
T12234	NMDA-IN-1		NMDAR
	NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM).		NMDAR
T23449	TCS 46b		NMDAR
	NR1A/NR2B NMDA receptor antagonist,orally active		NMDAR
T8920	Sepimostat		iGluR
	Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki v...		iGluR
T5522	NMDAR antagonist 1		Others , iGluR
	NMDAR antagonist 1 is an orally active, NR2B-selective NMDAR antagonist.		Others , iGluR
T8450	TCN 213	TCN213	NMDAR
	TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B		NMDAR
T23457	Threo Ifenprodil hemitartrate		Others
	σ receptor agonist and NR2B subunit-selective NMDA receptor antagonist		Others
T12758L	Ro 25-6981 Maleate		Others
	Ro 25-6981 Maleate is a potent and selective activity-dependent NMDA receptors blocker containing the NR2B subunit.(IC50 values are 0.009 and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respect...		Others
T23239	Ro 04-5595 hydrochloride		Others
	NR2B-containing NMDA receptors antagonist		Others