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Search Result

Search Results for " idh "

Targets

Isocitrate Dehydrogenase (IDH) Dehydrogenase

27

Compounds

2

Natural Products

2

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T15550 IDH-305 Dehydrogenase
IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor. IDH-305 shows greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50s: 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 µM (...
T2104 AGI-5198 IDH-C35 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
AGI-5198 (IDH-C35) is a highly effective and specific inhibitor of IDH1 R132H/R132C mutants (IC50: 0.07/0.16 μM).
T15551 IDH889 Dehydrogenase
IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).
T63380 IDH-C227
IDH-C227 is a selective and potent inhibitor of IDH1R132H that exhibits anticancer activity.
T16161 Mutant IDH1 inhibitor Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).
T12128 Mutant IDH1-IN-2 Isocitrate Dehydrogenase (IDH)
Mutant IDH1-IN-2 is a mutant Isocitrate dehydrogenase (IDH) proteins inhibitor
T2043 Mutant IDH1-IN-1 IDH1-IN-1 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Mutant IDH1-IN-1 is a potent mutant IDH1 R132 h inhibitor with IC50 < 0.1 uM.
TQ0042 BAY-1436032 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
BAY-1436032 is a novel, selective and orally available inhibitor of pan-mutant isocitrate dehydrogenase 1 (IDH1).
T7741 DS-1001b Dehydrogenase , Isocitrate Dehydrogenase (IDH)
DS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1)
T1809 AGI-6780 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
T2346 Enasidenib AG-221 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Enasidenib (AG-221) is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity.
T16384 Olutasidenib FT-2102 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain penetrant, and selective inhibitor of the mutant Iso...
T3617 Ivosidenib AG-120 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhi...
T7307 Vorasidenib PVM/MA,AG-881 Isocitrate Dehydrogenase (IDH)
Vorasidenib (PVM/MA) is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively)
T11611 IDH1 Inhibitor 2 Dehydrogenase
IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).
T11612 IDH1 Inhibitor 3 Others
IDH1 Inhibitor 3 is a mutant isocitric dehydrogenase 1 (IDH1) inhibitor (IC50: 45 nM for IDH1R132H).
T11613 IDH1 Inhibitor 1 Others
IDH1 Inhibitor 1 is an orally bioavailable, brain-penetrant, and selective mutant IDH1 inhibitor (IC50s: 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT).
T12129 Mutant IDH1-IN-4 Others
Mutant IDH1-IN-4 is an mutant Isocitrate dehydrogenase 1 (IDH 1) inhibitor.
T39716 Mutant IDH1-IN-6 Mutant IDH1-IN-6
Mutant IDH1-IN-6 is an orally active compound that effectively inhibits mutant isocitrate dehydrogenase (IDH) enzymes. It demonstrates potency and selectivity, with IC50 values of 6.27, 3.71, 36.9, and 11.5 nM for IDH1 R...
T79745 IDH2R140Q-IN-2 Dehydrogenase
IDH2R140Q-IN-2 is an orally active and potent IDH2R140Q inhibitor with an IC50 of 29 nM.IDH2R140Q-IN-2 possesses potential antitumour activity, reducing D2HG production in TF-1 cell lines carrying the IDH2R140Q mutation ...
T63403 WT IDH1 Inhibitor 2
WT IDH1 Inhibitor 2 is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor (IC50: 120 nM) and is a mutant R132H IDH1 inhibitor, an isoform of GSK321 with wild-type cross-reactivity.
T72705 IDH1 Inhibitor 7
IDH1 Inhibitor 7 is an IDH1 inhibitor with an IC 50 of less than 100 nM .
T63193 IDH2R140Q-IN-1
IDH2R140Q-IN-1 is a potent inhibitor of IDH2R140Q (IC50: 6.1 nM) and can be used in studies of acute myeloid leukemia.
T62725 IDH1 Inhibitor 5
IDH1 Inhibitor 5 (compound 2) is an inhibitor of IDH1 (isocitrate dehydrogenase 1), which inhibits MOG cells (IC50: 64.4 nM) and wild-type IDH1 glioma cells expressing exogenous mutant IDH1 R132H protein (IC50: 34.9 nM).
T62698 MIDH1-IN-1
mIDH1-IN-1 (compound 43) is a potent and selective inhibitor of mIDH1 (isocitrate dehydrogenase 1 mutant) (IC50: 961.5 nM). mIDH1-IN-1 effectively inhibits the production of 2-HG (2-hydroxyglutarate) in HT1080 cells (EC5...
T78758 IHMT-IDH1-053 Isocitrate Dehydrogenase (IDH)
IHMT-IDH1-053 (compound 16) is an irreversible inhibitor exhibiting high selectivity for the IDH1 R132H mutant, achieving an IC50 of 4.7 nM. It preferentially targets IDH1 mutants over wild-type IDH1 and IDH2, both wild-...
T63402 (S,R)-WT IDH1 Inhibitor 2
(S,R)-WT IDH1 Inhibitor 2 is a selective and potent mutant IDH1 inhibitor that inhibits R132G (IC50: 2.9 nM), R132C (IC50: 3.8 nM), R132H (IC50: 4.6 nM) and WT IDH1 (IC50: 46 nM) with 100-fold higher selectivity than IDH...

Compounds

IDH-305
T15550
Synonym:
Target: Dehydrogenase
AGI-5198
T2104
Synonym: IDH-C35
Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)
IDH889
T15551
Synonym:
Target: Dehydrogenase
IDH-C227
T63380
Synonym:
Target:
Mutant IDH1 inhibitor
T16161
Synonym:
Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)
Mutant IDH1-IN-2
T12128
Synonym:
Target: Isocitrate Dehydrogenase (IDH)
Mutant IDH1-IN-1
T2043
Synonym: IDH1-IN-1
Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)
BAY-1436032
TQ0042
Synonym:
Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)
DS-1001b
T7741
Synonym:
Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)
AGI-6780
T1809
Synonym:
Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)
Enasidenib
T2346
Synonym: AG-221
Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)
Olutasidenib
T16384
Synonym: FT-2102
Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)
Ivosidenib
T3617
Synonym: AG-120
Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)
Vorasidenib
T7307
Synonym: PVM/MA,AG-881
Target: Isocitrate Dehydrogenase (IDH)
IDH1 Inhibitor 2
T11611
Synonym:
Target: Dehydrogenase
IDH1 Inhibitor 3
T11612
Synonym:
Target: Others
IDH1 Inhibitor 1
T11613
Synonym:
Target: Others
Mutant IDH1-IN-4
T12129
Synonym:
Target: Others
Mutant IDH1-IN-6
T39716
Synonym: Mutant IDH1-IN-6
Target:
IDH2R140Q-IN-2
T79745
Synonym:
Target: Dehydrogenase
WT IDH1 Inhibitor 2
T63403
Synonym:
Target:
IDH1 Inhibitor 7
T72705
Synonym:
Target:
IDH2R140Q-IN-1
T63193
Synonym:
Target:
IDH1 Inhibitor 5
T62725
Synonym:
Target:
mIDH1-IN-1
T62698
Synonym:
Target:
IHMT-IDH1-053
T78758
Synonym:
Target: Isocitrate Dehydrogenase (IDH)
(S,R)-WT IDH1 Inhibitor 2
T63402
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T74193 (R)-IDHP
(R)-IDHP, an isomer of IDHP and a metabolite of salvia, exhibits vasorelaxant properties by inhibiting calcium (Ca 2+) release and inward flow through both voltage-dependent and receptor-operated calcium channels in vasc...
T3682 (-)-Catechin gallate (-)-Catechin 3-O-gallate,(-)-Catechin 3-gallate Others , COX
(-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of 6PGD, IDH. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of human Beta-secretase. (-)-Catechin gallate ((-)-Catechin 3-O-gallat...

Natural Products

(R)-IDHP
T74193
Synonym:
Target:
(-)-Catechin gallate
T3682
Synonym: (-)-Catechin 3-O-gallate,(-)-Catechin 3-gallate
Target: Others, COX

Recombinant Proteins

Species：
Human (2)
Expression System：
E. coli (2)
Tag：
C-6xHis (1)
His (1)
Cat No. Product Name Species Expression System
TMPY-02413 Isocitrate dehydrogenase/IDH1 Protein, Human, Recombinant (His) Human E. coli
Isocitrate dehydrogenase/IDH1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 48 kDa and the accession number is O75874.
TMPJ-01009 BLVRA Protein, Human, Recombinant (His) Human E. coli
Human Biliverdin reductase A (BLVRA) is belonged to the Gfo/Idh/MocA family and Biliverdin reductase subfamily. BLVRA is an enzyme that in humans is encoded by the BLVRA gene. BLVRA plays an important role in reducing th...
Cat No. Product Name
L2130 Anti-Cancer Metabolism Compound Library

1268 compounds
A unique collection of 1268 cancer cellular metabolism related compounds for cancer research and high throughput screening (HTS) and high content screening (HCS);

Libraries

Anti-Cancer Metabolism Compound Library
L2130
Compounds: 1268
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