Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 115.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 413.00 | |
25 mg | In stock | $ 690.00 | |
50 mg | 6-8 weeks | $ 983.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 272.00 |
Description | IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt). |
Targets&IC50 | IDH1 (R132C):0.072 μM, IDH1 (R132H):0.02 μM, IDH1 (WT):1.38 μM |
In vitro | IDH889 displays effective cellular inhibition of R-2-hydroxyglutarate (2-HG) production (IC50: 0.014 μM). |
Molecular Weight | 436.48 |
Formula | C23H25FN6O2 |
CAS No. | 1429179-07-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (137.46 mM), Sonification is recommended
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
IDH889 1429179-07-6 Metabolism Dehydrogenase Inhibitor inhibit Isocitrate Dehydrogenase (IDH) IDH 889 IDH-889 inhibitor