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Vorasidenib

Catalog No. T7307 CAS 1644545-52-7

Synonyms: PVM/MA共聚物, PVM/MA, AG-881

Vorasidenib is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively)

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Vorasidenib, CAS 1644545-52-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Vorasidenib is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively)
Targets&IC50	IDH1R132H:31.9 nM , IDH2R140Q:31.7 nM
In vivo	Vorsidenib reduces tumor growth in a TS603-IDH1R132H mouse xenograft model when administered at a dose of 50 mg/kg.

Synonyms	PVM/MA共聚物, PVM/MA, AG-881
Molecular Weight	414.74
Formula	C14H13ClF6N6
CAS No.	1644545-52-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (301.39 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zakkula A, Dittakavi S, Maniyar MM,et al.Validated HPLC method for simultaneous quantification of mutant IDH1/2 inhibitors (enasidenib, ivosidenib and vorasidenib) in mouse plasma: Application to a pharmacokinetic study[J].Biomed Chromatogr. 2019 Nov;33(11):e4658. 2. Tianfang M , Fangxia Z , Stefan P , et al. Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1/2): an Update and Perspective[J]. Journal of Medicinal Chemistry, 2018:acs.jmedchem.8b00159-.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Obesity Compound Library Lipid Metabolism Compound Library Glutamine Metabolism Compound Library Inhibitor Library Anti-Metabolism Disease Compound Library Covalent Inhibitor Library Drug Repurposing Compound Library

Related Products

Related compounds with same targets

BAY-1436032 DS-1001b Vorasidenib Ivosidenib Enasidenib AGI-5198 Mutant IDH1-IN-1 AGI-6780

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Vorasidenib 1644545-52-7 代谢 Isocitrate Dehydrogenase (IDH) inhibit PVM/MA AG 881 AG-881 AG881 Inhibitor inhibitor

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