18
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8922 | SRS11-92 | AA9 | Ferroptosis |
SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1 | |||
T8317 | 5'-Fluoroindirubinoxime | 5'-FIO | FLT |
5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM). | |||
T6500 | Ferrostatin-1 | Ferrostatin 1,Ferrostatin-1 (Fer-1) | Ferroptosis , Antifungal |
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of iron death. Ferrostatin-1 potently inhibits Erastin-induced iron death in HT-1080 cells with an EC50 of 60 nM. Ferrostatin-1 also exhibits antioxidant and anti... | |||
T4309 | CIL56 | CA3 | Ferroptosis , ROS |
CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyuns... | |||
T64343 | 3-Methylcarbazole | NSC 10154 | Others |
3-Methylcarbazole (NSC-10154) is an carbazole alkaloid compound with anticancer effects. | |||
T6334 | Ridaforolimus | AP23573,Deforolimus,MK-8669 | mTOR , Autophagy |
Ridaforolimus (AP23573) is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamyc... | |||
TN3307 | 9,10-Dimethoxycanthin-6-one | Others | |
9,10-Dimethoxycanthin-6-one shows cytotoxic activity against a HT-1080 human fibrosarcoma cell line( IC50 = 5.0 microM). | |||
TN3854 | Dihydroniloticin | Others | |
Dihydroniloticin shows cytotoxic activity against a HT-1080 human fibrosarcoma cell line( IC50 = 8.2 microM). | |||
T36398 | Paclitaxel octadecanedioate | ||
Paclitaxel octadecanedioate is a prodrug form of paclitaxel that is comprised of paclitaxel conjugated to 1,18-octadecanedioic acid.1 Unlike paclitaxel, it does not promote tubulin polymerization in vitro when used at a ... | |||
T32009 | GSK321 | GSK 321,GSK-321 | |
GSK321 is an effective and selective IDH1 mutation inhibitor, which can effectively inhibit the production of 2-HG in HT-1080 cells, and induce IDH1 mutant cells to differentiate into bone marrow at the level of leukemia... | |||
T70527 | DAT-230 | ||
DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230 -tr... | |||
T35994 | Erastin2 | Erastin2 | |
Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.[1] [2] It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM).[2] It induces cell death in HAP1 cells... | |||
T36404 | PRLX-93936 | ||
PRLX-93936 is an analog of erastin that has antitumor activity. It inhibits the hypoxia-inducible factor 1 (HIF-1) signaling pathway under hypoxic conditions (IC50 = 0.09 μM in a cell-based reporter assay). PRLX-93936 (1... | |||
T82408 | Ferroptosis-IN-3 | Ferroptosis | |
Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM). It exhibits radical scavenging abilities against DPPH and ABTS... | |||
T82767 | CC-3060 | ||
CC-3060 is a potent Cereblon modulator that facilitates the degradation of ZBTB16, exhibiting a DC50 of 0.47 nM in HT-1080 cells. It orchestrates ZBTB16 degradation by targeting discrete structural degrons within various... | |||
TN3571 | Calyxin B | Others | |
Calyxin B exhibits potent activity against human HT-1080 fibrosarcoma cells with an ED50 value of 0.69 microM. A methylated product of calyxin A and an epimeric mixture of Calyxin B, showed greatly reduced activity sugge... | |||
T83780 | GPX4 24 | Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24 | |
GPX4 24, a derivative of (1S,3R)-RSL3, acts as a potent inhibitor of glutathione peroxidase 4 (GPX4) through covalent binding in a concentration-dependent manner within 4T1 murine mammary carcinoma cells. This compound e... | |||
T83886 | IcFSP1 TFA | ||
icFSP1, an inhibitor of ferroptosis suppressor protein 1 (FSP1), promotes condensation and phase separation of FSP1 in cellular environments at 2.5 µM concentration but does not affect FSP1's enzymatic function in cell-f... |