hif-2α — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T15482	HIF-2α-IN-1		HIF
	HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.		HIF
T11561	HIF-2α-IN-2		HIF/HIF Prolyl-Hydroxylase , HIF
	HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).		HIF/HIF Prolyl-Hydroxylase , HIF
T67831	HIF-2α agonist 2		HIF/HIF Prolyl-Hydroxylase , HIF
	HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structure of HIF-2a-ARNT complex without cytotoxicity to 786-o-Reh...		HIF/HIF Prolyl-Hydroxylase , HIF
T50099	HIF-2α-IN-4		Others , HIF/HIF Prolyl-Hydroxylase
	HIF-2a translation inhibitor is a compound used as a molecular building block.		Others , HIF/HIF Prolyl-Hydroxylase
T11562	HIF-2α-IN-3		HIF
	HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.		HIF
T36711	FM19G11	FM19G11,HIF-1alpha/2alpha Inhibitor	HIF
	FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).		HIF
T29797	AKB-6899	AKB6899	VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF
	AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which in...		VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF
T61367	HIF-2α-IN-6
	HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].
T72997	HIF-2α-IN-7
	HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor. HIF-2α-IN-7 can inhibit HIF-2α with an EC 50 value of 6 nM. HIF-2α-IN-7 can be used for the research of various types of diseases including cancer , liver ...
T61614	HIF-2α-IN-5
	HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].
T78937	HIF-2α-IN-9		HIF/HIF Prolyl-Hydroxylase
	HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes within tumor cells while reactivating macrophage-mediated tumor immun...		HIF/HIF Prolyl-Hydroxylase
T61102	HIF-1/2α-IN-2
	HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α. This compound elicits an iron starvation response by specifically targeting ISCA2, a key protein involved in Iron Sulfur ...
T0692	Allopurinol	Zyloric,Zyloprim,Lopurin	ROS , Xanthine Oxidase
	Allopurinol (Zyloric) is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.		ROS , Xanthine Oxidase
T61442	HIF-1/2α-IN-1
	HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α. Its inhibitory effect on HIF-2α activity is significant, with an IC 50 value of 0.92 μM. Furthermore, HIF-1/2α-IN-1 has the ability to decrea...
T6376	Allopurinol Sodium	Allopurinol sodium salt,Sodium allopurinol	ROS
	Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.		ROS
T17009	TC-S 7009		HIF
	TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM). The affinity of TC-S 7009 to HIF-2α was higher than that of HIF-1α (Kd >> 5μM). TC-S 7009 disrupts HIF-2α heterodimerization, reduces HIF-2α target gene e...		HIF
T7802	M1001		HIF/HIF Prolyl-Hydroxylase , HIF
	M1001 is a HIF-2α agonist.		HIF/HIF Prolyl-Hydroxylase , HIF
T7848	PT-2385		HIF/HIF Prolyl-Hydroxylase , HIF
	PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).		HIF/HIF Prolyl-Hydroxylase , HIF
T12675L	PT2399		HIF/HIF Prolyl-Hydroxylase , HIF
	PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50: 6 nM).		HIF/HIF Prolyl-Hydroxylase , HIF
T16679	Belzutifan	PT2977,MK-6482	HIF
	Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2α inhibitor,...		HIF