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TC-S 7009

Catalog No. T17009 CAS 1422955-31-4

TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM). The affinity of TC-S 7009 to HIF-2α was higher than that of HIF-1α (Kd << 5μM). TC-S 7009 disrupts HIF-2α heterodimerization, reduces HIF-2α target gene expression, and reduces dna binding activity.

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TC-S 7009, CAS 1422955-31-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 64.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 247.00
50 mg	In stock	$ 368.00
100 mg	In stock	$ 543.00
1 mL * 10 mM (in DMSO)	In stock	$ 70.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM). The affinity of TC-S 7009 to HIF-2α was higher than that of HIF-1α (Kd >> 5μM). TC-S 7009 disrupts HIF-2α heterodimerization, reduces HIF-2α target gene expression, and reduces dna binding activity.
Targets&IC50	HIF2α:81 nM(kd)
In vitro	TC-S 7009 (50 μM) treatment almost fully inhibits hypoxia-induced NFATc2 nuclear translocation. TC-S 7009 (0-100 µM; 72 hours; HPF cells) treatment displays greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions [2].

Molecular Weight	308.65
Formula	C12H6ClFN4O3
CAS No.	1422955-31-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.0 mg/mL (145.8 mM), Sonication is recommended.

References and Literature

1. Scheuermann TH, et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol. 2013;9(4):271-276. 2. Senavirathna LK, et al. Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Sci Rep. 2018;8(1):2709.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

Oligomycin PX-478 ENMD-1198 Demethyleneberberine HIF-2α-IN-3 HIF-1 inhibitor-4 Pantoprazole sodium Myricanol

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TC-S 7009 1422955-31-4 Angiogenesis Chromatin/Epigenetic HIF TC-S-7009 TC-S7009 TCS 7009 TC S 7009 inhibitor inhibit

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