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Search Results for " gamma-secretase "

20

Compounds

Cat No. Product Name Synonyms Targets
T11358 gamma-secretase modulator 1 N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine Gamma-secretase
gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.
T11360 gamma-secretase modulator 3 Others
gamma-secretase modulator 3 is a gamma-secretase modulator.
T11359 gamma-secretase modulator 2 Others
Gamma-secretase modulator 2 is a potent, selective compound for the treatment of Alzheimer's disease, specifically designed to modulate γ-secretase activity. This modulation selectively attenuates the production of Aβ(1-...
T11362 gamma-Secretase Modulators γ-Secretase Modulators,Amyloid-β production inhibitor Others
gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.
T6135 YO-01027 gamma-Secretase Inhibitor XX,Dibenzazepine,DBZ Gamma-secretase
YO-01027 (DBZ) is a potent γ-secretase inhibitor.
T11358L gamma-secretase modulator 1 hydrochloride gamma-secretase modulator 1 hydrochloride (1172637-87-4 free base) Others
gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].
T9422 Fosciclopirox CPX-POM Gamma-secretase
Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire urinary tract following parenteral administration.
T16294 NGP555 Gamma-secretase
NGP555 is a modulator of γ-secretase.
T6063 LY-411575 LY411575 Apoptosis , Gamma-secretase
LY-411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39 nM.
T2625 MK-0752 Beta Amyloid , Gamma-secretase
MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
T6249 Avagacestat BMS-708163 Gamma-secretase
Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
T3633 Crenigacestat LY3039478 Gamma-secretase
Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor mo...
T6870 L-685458 L-685,458 Apoptosis , Gamma-secretase
L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
T16133 MRK-560 Gamma-secretase
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.
T6274 RO4929097 RG-4733 Beta Amyloid , Gamma-secretase
RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).
T6125 Semagacestat LY450139 Beta Amyloid , Gamma-secretase
Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
T2262 Itanapraced CHF5074,CSP-1103 Beta Amyloid , Gamma-secretase
Itanapraced (CHF5074), a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
T6202 DAPT LY-374973,GSI-IX Apoptosis , Beta Amyloid , Gamma-secretase , Autophagy
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis.
T64258 gamma-secretase modulator 5
gamma-secretase modulator 5 (compound 22d) is a gamma-secretase modulator (GSMs) that crosses the blood-brain barrier and exhibits an inhibitory effect on the production of the aggregated amyloid β peptide Aβ42 (IC50: 60...
T6935 Nirogacestat PF-03084014,PF-3084014,PF03084014,PF 03084014 Apoptosis , Gamma-secretase
Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).

Compounds

gamma-secretase modulator 1
T11358
Synonym: N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine
Target: Gamma-secretase
gamma-secretase modulator 3
T11360
Synonym:
Target: Others
gamma-secretase modulator 2
T11359
Synonym:
Target: Others
gamma-Secretase Modulators
T11362
Synonym: γ-Secretase Modulators,Amyloid-β production inhibitor
Target: Others
YO-01027
T6135
Synonym: gamma-Secretase Inhibitor XX,Dibenzazepine,DBZ
Target: Gamma-secretase
gamma-secretase modulator 1 hydrochloride
T11358L
Synonym: gamma-secretase modulator 1 hydrochloride (1172637-87-4 free base)
Target: Others
Fosciclopirox
T9422
Synonym: CPX-POM
Target: Gamma-secretase
NGP555
T16294
Synonym:
Target: Gamma-secretase
LY-411575
T6063
Synonym: LY411575
Target: Apoptosis, Gamma-secretase
MK-0752
T2625
Synonym:
Target: Beta Amyloid, Gamma-secretase
Avagacestat
T6249
Synonym: BMS-708163
Target: Gamma-secretase
Crenigacestat
T3633
Synonym: LY3039478
Target: Gamma-secretase
L-685458
T6870
Synonym: L-685,458
Target: Apoptosis, Gamma-secretase
MRK-560
T16133
Synonym:
Target: Gamma-secretase
RO4929097
T6274
Synonym: RG-4733
Target: Beta Amyloid, Gamma-secretase
Semagacestat
T6125
Synonym: LY450139
Target: Beta Amyloid, Gamma-secretase
Itanapraced
T2262
Synonym: CHF5074,CSP-1103
Target: Beta Amyloid, Gamma-secretase
DAPT
T6202
Synonym: LY-374973,GSI-IX
Target: Apoptosis, Beta Amyloid, Gamma-secretase, Autophagy
gamma-secretase modulator 5
T64258
Synonym:
Target:
Nirogacestat
T6935
Synonym: PF-03084014,PF-3084014,PF03084014,PF 03084014
Target: Apoptosis, Gamma-secretase
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TargetMol