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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11358 | gamma-secretase modulator 1 | N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine | Gamma-secretase |
gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease. | |||
T11360 | gamma-secretase modulator 3 | Others | |
gamma-secretase modulator 3 is a gamma-secretase modulator. | |||
T11359 | gamma-secretase modulator 2 | Others | |
Gamma-secretase modulator 2 is a potent, selective compound for the treatment of Alzheimer's disease, specifically designed to modulate γ-secretase activity. This modulation selectively attenuates the production of Aβ(1-... | |||
T11362 | gamma-Secretase Modulators | γ-Secretase Modulators,Amyloid-β production inhibitor | Others |
gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value. | |||
T6135 | YO-01027 | gamma-Secretase Inhibitor XX,Dibenzazepine,DBZ | Gamma-secretase |
YO-01027 (DBZ) is a potent γ-secretase inhibitor. | |||
T11358L | gamma-secretase modulator 1 hydrochloride | gamma-secretase modulator 1 hydrochloride (1172637-87-4 free base) | Others |
gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1]. | |||
T9422 | Fosciclopirox | CPX-POM | Gamma-secretase |
Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire urinary tract following parenteral administration. | |||
T16294 | NGP555 | Gamma-secretase | |
NGP555 is a modulator of γ-secretase. | |||
T6063 | LY-411575 | LY411575 | Apoptosis , Gamma-secretase |
LY-411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39 nM. | |||
T2625 | MK-0752 | Beta Amyloid , Gamma-secretase | |
MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM). | |||
T6249 | Avagacestat | BMS-708163 | Gamma-secretase |
Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2. | |||
T3633 | Crenigacestat | LY3039478 | Gamma-secretase |
Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor mo... | |||
T6870 | L-685458 | L-685,458 | Apoptosis , Gamma-secretase |
L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. | |||
T16133 | MRK-560 | Gamma-secretase | |
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase. | |||
T6274 | RO4929097 | RG-4733 | Beta Amyloid , Gamma-secretase |
RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM). | |||
T6125 | Semagacestat | LY450139 | Beta Amyloid , Gamma-secretase |
Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM). | |||
T2262 | Itanapraced | CHF5074,CSP-1103 | Beta Amyloid , Gamma-secretase |
Itanapraced (CHF5074), a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM). | |||
T6202 | DAPT | LY-374973,GSI-IX | Apoptosis , Beta Amyloid , Gamma-secretase , Autophagy |
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis. | |||
T64258 | gamma-secretase modulator 5 | ||
gamma-secretase modulator 5 (compound 22d) is a gamma-secretase modulator (GSMs) that crosses the blood-brain barrier and exhibits an inhibitory effect on the production of the aggregated amyloid β peptide Aβ42 (IC50: 60... | |||
T6935 | Nirogacestat | PF-03084014,PF-3084014,PF03084014,PF 03084014 | Apoptosis , Gamma-secretase |
Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay). |