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Catalog No. T2262   CAS 749269-83-8
Synonyms: CHF5074, CSP-1103

Itanapraced (CHF5074), a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).

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Itanapraced Chemical Structure
Itanapraced, CAS 749269-83-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 31.00
2 mg In stock $ 44.00
5 mg In stock $ 72.00
10 mg In stock $ 113.00
25 mg In stock $ 228.00
50 mg In stock $ 363.00
100 mg In stock $ 547.00
1 mL * 10 mM (in DMSO) In stock $ 79.00
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Purity: 99.79%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Itanapraced (CHF5074), a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
Targets&IC50 Aβ40:18.4 μM, Aβ42:3.6μM
Kinase Assay GSK-3β activity assay: IC50 of new synthesised compound IM-12 to GSK-3β is determined by a luminometric GSK-3β activity assay. Briefly, compounds are tested in different concentrations diluted in assay buffer containing final concentrations of: 4 mM MOPS pH 7.2; 0.4 mM EDTA; 1 mM EGTA; 2.5 mM β-glycerophosphate; 4 mM MgCl2; 40 μM BSA; 0.05 mM DTT. Four microlitres of diluted compounds are added to 25 μM pGS-2 peptide substrate, 20 ng recombinant GSK-3β and 1 μM ATP to a total assay volume of 40 μl. The enzymatic reaction is stopped after 30 min of incubation at 30 °C by adding 40 μl KinaseGlo. The luminometric signal is allowed to stabilise for 10 min and the measured with a Glomax? 96 Microplate Luminometer.
Synonyms CHF5074, CSP-1103
Molecular Weight 325.16
Formula C16H11Cl2FO2
CAS No. 749269-83-8


Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (153.77 mM)

TargetMolReferences and Literature

1. Imbimbo BP, et al. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. 2. Ronsisvalle N, et al. Curr Alzheimer Res. 2014;11(7):714-24.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Anti-Parkinson's Disease Compound Library Protease Inhibitor Library Bioactive Compounds Library Max NO PAINS Compound Library Reprogramming Compound Library Anti-Alzheimer's Disease Compound Library Stem Cell Differentiation Compound Library ReFRAME Related Library

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Itanapraced 749269-83-8 Neuroscience Proteases/Proteasome Stem Cells Beta Amyloid Gamma-secretase CSP 1103 Inhibitor CHF 5074 Gamma secretase γ-secretase CSP1103 CHF5074 CSP-1103 inhibit CHF-5074 inhibitor