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NGP555

Catalog No. T16294 CAS 1304630-27-0

NGP555 is a modulator of γ-secretase.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

NGP555, CAS 1304630-27-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 71.00
2 mg	In stock	$ 101.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 308.00
25 mg	In stock	$ 519.00
50 mg	In stock	$ 753.00
100 mg	In stock	$ 1,060.00
1 mL * 10 mM (in DMSO)	In stock	$ 215.00

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Purity: 99.77%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NGP555 is a modulator of γ-secretase.
In vitro	NGP555 effectively lowers Aβ42 in cell cultures (9 nM) and increasing shorter forms of Aβ at the same time .
In vivo	NGP555 also shows good oral bioavailability and is brain-penetrant with a brain: plasma ratio of ~0.93 in mice. NGP555-treated Tg mice show significant protection from a decline in performance with >65% less decline (P<0.005) when comparing the differential of Tg to non-Tg vehicle-treated mice. NGP555 obviously lowers Aβ42 in the cerebrospinal fluid (CSF) at time points from 8 to10 hours post-dose. When combining the reduction of Aβ42 with an increase in Aβ38, NGP555 is effective at raising CSF Aβ38/42 ratio at 1.87 mg/kg and above .

Molecular Weight	406.52
Formula	C23H23FN4S
CAS No.	1304630-27-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (61.50 mM), Sonification is recommended.

References and Literature

1. Kounnas MZ, et al. NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents. Alzheimers Dement (N Y). 2017 Jan;3(1):65-73.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Anti-Alzheimer's Disease Compound Library Bioactive Compounds Library Max NO PAINS Compound Library ReFRAME Related Library Clinical Compound Library Bioactive Compound Library Anti-Aging Compound Library Stem Cell Differentiation Compound Library

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Legumain inhibitor 1 Itanapraced Gossypolone Psoralidin ELN318463 racemate γ-Secretase-IN-1 CIA-1 (Free base) Crenigacestat

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NGP555 1304630-27-0 Neuroscience Proteases/Proteasome Stem Cells Gamma-secretase Inhibitor γ-secretase inhibit NGP-555 NGP 555 Gamma secretase inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.