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Search Results for " gp130 "

11

Compounds

Cat No. Product Name Synonyms Targets
T9157 GP130 receptor agonist-1 N-(4-Fluorophenyl)-4-phenyl-2-thiazolami Interleukin
GP130 receptor agonist-1 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami) is a potent, brain-penetrant and orally active GP130 receptor agonist.
T2544 Bazedoxifene acetate WAY-TES 424,TSE 424,WAY-140424 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM).
T6404 Bazedoxifene hydrochloride Bazedoxifene HCl,TSE-424 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Bazedoxifene hydrochloride (TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively.
T6207 SC144 Apoptosis , Interleukin
SC144 is an orally active small-molecule gp130 inhibitor.
T5359 RCGD423 Interleukin
RCGD423, a small molecule gp130 modulator, prevents articular cartilage degeneration and promotes repair.
T77672 JI069 WAY-354189 JAK , STAT
JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1.
T15769 LMT-28 IL Receptor
LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2.
T41260 SC144 hydrochloride
SC144 hydrochloride, a first-in-class, orally active, small-molecule gp130 (IL6-beta) inhibitor, demonstrates potent inhibition of gp130 ligand-triggered signaling. By binding to gp130, it initiates gp130 phosphorylation...
T72754 JAK2/STAT3-IN-1
JAK2/STAT3-IN-1 -10a) is a potent inhibitor of GP130, exhibiting an IC50 value of 3.04 µM and demonstrating anti-tumor activity.
T19728 SPRC S-Propargyl-cysteine
SPRC is a novel synthetic molecule exerting antioxidant effects via elevating the generation of endogenous H2S. SPRC activates Gp130-mediated STAT3 and prevents doxorubicin-induced cardiotoxicity.
T74734 Truncated ADR58
Truncated ADR58, derived by shortening full-length ADR58 from 71 bases to 31 bases, maintains comparable functional activity to its full-length counterpart. This compound acts as a potent and selective antagonist of huma...
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