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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9157 | GP130 receptor agonist-1 | N-(4-Fluorophenyl)-4-phenyl-2-thiazolami | Interleukin |
GP130 receptor agonist-1 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami) is a potent, brain-penetrant and orally active GP130 receptor agonist. | |||
T2544 | Bazedoxifene acetate | WAY-TES 424,TSE 424,WAY-140424 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM). | |||
T6404 | Bazedoxifene hydrochloride | Bazedoxifene HCl,TSE-424 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Bazedoxifene hydrochloride (TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively. | |||
T6207 | SC144 | Apoptosis , Interleukin | |
SC144 is an orally active small-molecule gp130 inhibitor. | |||
T5359 | RCGD423 | Interleukin | |
RCGD423, a small molecule gp130 modulator, prevents articular cartilage degeneration and promotes repair. | |||
T77672 | JI069 | WAY-354189 | JAK , STAT |
JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1. | |||
T15769 | LMT-28 | IL Receptor | |
LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2. | |||
T41260 | SC144 hydrochloride | ||
SC144 hydrochloride, a first-in-class, orally active, small-molecule gp130 (IL6-beta) inhibitor, demonstrates potent inhibition of gp130 ligand-triggered signaling. By binding to gp130, it initiates gp130 phosphorylation... | |||
T72754 | JAK2/STAT3-IN-1 | ||
JAK2/STAT3-IN-1 -10a) is a potent inhibitor of GP130, exhibiting an IC50 value of 3.04 µM and demonstrating anti-tumor activity. | |||
T19728 | SPRC | S-Propargyl-cysteine | |
SPRC is a novel synthetic molecule exerting antioxidant effects via elevating the generation of endogenous H2S. SPRC activates Gp130-mediated STAT3 and prevents doxorubicin-induced cardiotoxicity. | |||
T74734 | Truncated ADR58 | ||
Truncated ADR58, derived by shortening full-length ADR58 from 71 bases to 31 bases, maintains comparable functional activity to its full-length counterpart. This compound acts as a potent and selective antagonist of huma... |