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Search Result

Search Results for " ggt "

Targets

Apoptosis Others

25

Compounds

2

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T15411 GPNA hydrochloride Apoptosis , Others
GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT)....
T25450L GGTI 2147 FA GGTI2147 FA,GGTI-2147 FA,GGTI 2147 FA(191102-87-1 Free base) Others
GGTI 2147 FA, a selective GGT inhibitor, abolishes bicuculline-induced increase in dendritic spine density in hippocampal experiments and may reduce learning and memory abilities in mice.
T6844 GGTI298 Trifluoroacetate GGTI 298,GGTI 298 TFA salt Apoptosis , Transferase , Ras
GGTI298 Trifluoroacetate (GGTI 298 TFA salt) is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.
T24088 GGTI-2133 GGTI2133,GGTI 2133 Transferase
GGTI-2133 is a potent mimetic peptidyl geranylgeranyltransferase type I inhibitor (GGTase I) with an IC50 value of 38 nM.GGTI-2133 inhibits the invasion of inflammatory cells into the airways in experimental asthma in mi...
T25450 GGTI 2147 GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147 NF-κB , Rho
GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.
T27412 GGTI2417 GGTI-2417
GGTI2417 is a potent and selective inhibitor of Geranylgeranyltransferase I. GGTI2417 targets RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.
T11397 GGTI298 Others
GGTI298, a CAAZ peptidomimetic and potent geranylgeranyltransferase I (GGTase I) inhibitor, efficiently blocks the processing of geranylgeranylated Rap1A while exerting minimal impact on the processing of farnesylated Ha...
T70157 GGTI-297
GGTI-297 is a potent, cell-permeable, and selective peptidomimetic inhibitor of GGTase I compared to Farnesyl Transferase (FTase).
T37446 GGTI-2154
GGTI-2154 is a potent, selective geranylgeranyltransferase I (GGTase I) inhibitor, boasting an IC50 of 21 nM and demonstrating over 200-fold selectivity against FTase (IC50=5600 nM). Its efficacy and specificity make it ...
T62379 GGTI-286
GGTI-286 is a potent, cell permeable GGTase I inhibitor (IC50: 2 μM). GGTI-286 inhibits Rap1A geranylation in NIH3T3 cells (IC50: 2 μM) more potently than H-Ras farnesylation (IC50>30 μM). Ras4B stimulation (IC50: 1 μM).
T62844 GGTI-2154 hydrochloride
GGTI-2154 hydrochloride is a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I) (IC50: 21 nM). GGTI-2154 hydrochloride can be used in cancer research.
T11396 GGTI-2418 Transferase
GGTI-2418 is a highly potent, competitive, and selective inhibitor of geranylgeranyltransferase I (GGTase I), showing inhibitory activities with IC50 values of 9.5 nM for GGTase I and 53 μM for FTase, respectively. Addit...
T62980 GGTI-286 hydrochloride
GGTI-286 hydrochloride is a potent inhibitor of GGTase I (IC50: 2 μM) and is also effective in inhibiting K-Ras4B (IC50: 1 μM). farnesylation (IC50=2 and >30 μM).
T73822 GGTI-286 TFA
GGTI-286 TFA is a potent, cell-permeable inhibitor of GGTase I, exhibiting 25 times greater effectiveness (IC 50 = 2 μM) compared to the corresponding methyl ester of FTI-276. It specifically targets the geranylgeranylat...
T69205 GGTI-2166
GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent mo...
T5415 γ-GT H-GLA(PNA)-OH Others
γ-GT (H-GLA(PNA)-OH) is used as a synthetic substrate for gamma-glutamyltransferase (GGT) to determine GGT activity.
T22128 OU749 Transferase
OU749 is a γ-glutamyl transferase (GGT) inhibitor with an intrinsic Ki of 17.6 μM.
T11282 FGTI-2734 Transferase
FGTI-2734 is a dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor, exhibiting IC50 values of 250 nM and 520 nM for FT and GGT-1, respectively. It effectively prevents the membrane localizat...
T11282L FGTI-2734 mesylate (1247018-19-4 free base) FGTI-2734 mesylate Others
FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates ...
T15379 GGsTop Nahlsgen Others
GGsTop is a non-toxic and irreversible inhibitor of γ glutamyl transpeptidase (GGT) (Ki: 170 μM for Human GGT). GGsTop protects hepatic ischemia-reperfusion injury in the rat model. GGsTop shows Kons of 150±10 and 51±3 /...
T20638 Silthiofam MON 65500,Silthiopham,Latitude,MON65500,MON-65500
Silthiofam is very effective against Gaeumannomyces graminis var. tritici (Ggt), recently it has been widely used for the take-all control in China. Ggt could cause Wheat take-all.
T11330 FTI-2148 diTFA Others
FTI-2148 diTFA, a dual inhibitor targeting both farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1), functions as a RAS C-terminal mimetic. It exhibits potent inhibitory capabilities with IC50 values of ...
T11330L FTI-2148 Others
FTI-2148 is an inhibitor of RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) (IC50s: 1.4 nM and 1.7 μM, respectively).
T82852 BMI-Glu
BMI-Glu, a selective γ-glutamyl transpeptidase (GGT) fluorescent probe, exhibits a Michaelis constant (Km) of 69.63 µM and is characterized by its high sensitivity, good water solubility, and biocompatibility [1].
T81233 S-(p-Nitrobenzyl)glutathione
S-(p-Nitrobenzyl)glutathione acts as a competitive inhibitor of glutathionase. Rat kidney microsomes convert this compound into associated cysteine derivatives. It serves as a research tool in investigating the catabolis...
Cat No. Product Name Synonyms Targets
T14114 Acivicin AT-125,U-42126 Others
Acivicin (AT-125) is a γ-glutamyl transpeptidase (GGT) inhibitor derived from the Streptomyces sviceus natural product. It possesses anti-cancer and anti-parasitic properties and can effectively cross the blood-brain bar...
T77207 Acivicin hydrochloride
Acivicin hydrochloride (AT-125 hydrochloride), derived from Streptomyces sviceus, functions as a γ-glutamyl transpeptidase (GGT) inhibitor. This compound possesses the ability to cross the blood-brain barrier and demonst...

Natural Products

Acivicin
T14114
Synonym: AT-125,U-42126
Target: Others
Acivicin hydrochloride
T77207
Synonym:
Target:

Recombinant Proteins

Species：
Human (2)
Rat (1)
Expression System：
HEK293 Cells (3)
Tag：
C-His (1)
His (1)
N-His (1)
Cat No. Product Name Species Expression System
TMPY-06971 GGT1 Protein, Human, Recombinant (His) Human HEK293 Cells
GGT1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.05 kDa and the accession number is P19440.2.
TMPY-00196 GGT5 Protein, Human, Recombinant (His) Human HEK293 Cells
GGT5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 61.8 kDa and the accession number is P36269-1.
TMPY-03115 GGT1 Protein, Rat, Recombinant (His) Rat HEK293 Cells
GGT1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 61.1 kDa and the accession number is P07314.
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