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GGTI2417

Catalog No. T27412 CAS 501010-05-5

Synonyms: GGTI-2417

GGTI2417 is a potent and selective inhibitor of Geranylgeranyltransferase I. GGTI2417 targets RalB to inhibit anchorage-dependent growth and induce Apoptosis and RalA to inhibit anchorage-independent growth.

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GGTI2417, CAS 501010-05-5

Pack Size	Availability	Price/USD
5 mg	8-10 weeks	$ 1,170.00 $ 936.00
50 mg	8-10 weeks	$ 2,380.00 $ 1,904.00
100 mg	8-10 weeks	$ 3,100.00 $ 2,480.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

GGTI2417 is a potent and selective inhibitor of Geranylgeranyltransferase I. GGTI2417 targets RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.

Synonyms	GGTI-2417
Molecular Weight	455.55
Formula	C24H33N5O4
CAS No.	501010-05-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kazi A, Carie A, Blaskovich MA, Bucher C, Thai V, Moulder S, Peng H, Carrico D, Pusateri E, Pledger WJ, Berndt N, Hamilton A, Sebti SM. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy. Mol Cell Biol. 2009 Apr;29(8):2254-63. doi: 10.1128/MCB.01029-08. Epub 2009 Feb 9. PubMed PMID: 19204084; PubMed Central PMCID: PMC2663293. 2. Falsetti SC, Wang DA, Peng H, Carrico D, Cox AD, Der CJ, Hamilton AD, Sebti SM. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. Mol Cell Biol. 2007 Nov;27(22):8003-14. Epub 2007 Sep 17. PubMed PMID: 17875936; PubMed Central PMCID: PMC2169159.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GGTI2417 501010-05-5 GGTI-2417 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.