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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T39057 | Rozanolixizumab | UCB7665 | Others |
Rozanolixizumab (RYSTIGGO) is a high-affinity humanized immunoglobulin G4 monoclonal antibody targeting Fc receptors (FcRn) in human newborns for the study of pathogenic IgG in autoimmune and alloimmune diseases. | |||
T78325 | Orilanolimab | SYNT001 | |
Orilanolimab (SYNT001) is a humanized, de-immunized monoclonal antibody that inhibits the FcRn-IgG interaction, thereby disrupting IgG homeostasis and impeding FcRn-mediated adaptive immune responses, as well as related ... | |||
T78249 | Nipocalimab | M281 | |
Nipocalimab (M281), a fully human, recombinant, aglycosylated IgG1 monoclonal antibody, exhibits high-affinity binding to the Fc receptor (FcRn) at both endosomal pH 6.0 and extracellular pH 7.6, characterized by its pic... | |||
T78245 | Batoclimab | IMVT-1401,HBM9161 | |
Batoclimab, a human anti-FcRn monoclonal antibody, is utilized in the study of IgG-mediated autoimmune diseases [1]. | |||
T9901A-010 | Tifalibep | ABY-039 | |
Tifalibep (ABY-039) is a bivalent anti-FcRn antibody mimetic that can be used to treat antibody (IgG)-mediated autoimmunity. | |||
T77190 | Crovalimab | ||
Crovalimab (SKY59; RO7112689) is a novel humanized antibody designed to target C5 in a pH-dependent manner, demonstrating binding affinities (KD) of 15.2 nM and 16.8 μM at pH levels of 7.4 and 5.8, respectively. Addition... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02811 | FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.5 kDa and the accession number is Q61559&P01887. | |||
TMPY-05539 | FCGRT & B2M Heterodimer Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.5 kDa and the accession number is P55899&P61769. | |||
TMPY-02082 | FCGRT & B2M Heterodimer Protein, Human, Recombinant (His) | Human | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.5 kDa and the accession number is P55899-1&P61769. | |||
TMPY-05649 | FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 46 kDa and the accession number is Q61559. | |||
TMPY-05147 | FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.2 kDa and the accession number is Q61559&P01887. | |||
TMPY-05036 | FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 45.3 kDa and the accession number is NP_004098.1&NP_004039.1. | |||
TMPY-05448 | FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 45.3 kDa and the accession number is NP_004098.... | |||
TMPH-01517 | FCGRT Protein, Human, Recombinant (GST) | Human | E. coli |
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound... | |||
TMPH-01516 | FCGRT Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound... | |||
TMPK-01115 | Fc gamma RIII/CD16 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human Fc gamma RI, ... |