endoxifen — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4281	Endoxifen	(E/Z)-N-desmethyl-4-hydroxy Tamoxifen,(E/Z)-Endoxifen	Estrogen Receptor/ERR , Aromatase , Estrogen/progestogen Receptor , Parasite , Drug Metabolite
	(E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-f...
T11200	Endoxifen (E-isomer)	E-Endoxifen,Endoxifen E-isomer	Estrogen Receptor/ERR
	Endoxifen E-isomer (E-Endoxifen) is the E-isomer of (Z)-Endoxifen. Endoxifen E-isomer has antiestrogenic effects.		Estrogen Receptor/ERR
T2280	Endoxifen (Z-isomer)	Endoxifen Z-isomer	Estrogen Receptor/ERR , EGFR , Potassium Channel , Estrogen/progestogen Receptor , HER
	Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.
T6827L	Endoxifen hydrochloride
	Endoxifen hydrochloride, a principal active metabolite of Tamoxifen (TAM), exhibits heightened affinity and specificity towards the estrogen receptor and possesses aromatase inhibitory capability. It holds promise for br...
T6827	Endoxifen Z-isomer hydrochloride	Endoxifen HCl	Estrogen Receptor/ERR , Potassium Channel , Estrogen/progestogen Receptor , HER
	Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
T3645	Endoxifen E-isomer hydrochloride	E-Endoxifen hydrochloride	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride) , a tamoxifen metabolite, is effective specific Estrogen Response Modifier (SERM).		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T71578	Endoxifen mesylate
	Endoxifen, also known as N-desmethyl-4-hydroxytamoxifen, is a chemical that is under development for estrogen receptor-positive breast cancer. It is also being evaluated as an antipsychotic for treatment of mania and ot...
T71576	SIM010603
	SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived g...
T12482	Pipendoxifene hydrochloride		Estrogen Receptor/ERR
	Pipendoxifene hydrochloride is a selective modulator of estrogen receptor.		Estrogen Receptor/ERR
T70013	Pipendoxifene
	Pipendoxifene, also known as ERA-923, is a new antiestrogen with potential anticancer activity. ERA-923 potently inhibits estrogen binding to ER-alpha (IC50 = 14 nM). In ER-alpha-positive human MCF-7 breast carcinoma cel...
T71010	Norendoxifen
	Norendoxifen, also known as 4-hydroxy-N, N-didesmethyltamoxifen, is a nonsteroidal aromatase inhibitor of the triphenylethylene group that was never marketed. It is an active metabolite of the selective estrogen receptor...
T74458	EGFR-IN-43
	EGFR-IN-43 (Compound 17c) is a highly effective EGFR inhibitor, exhibiting activity in the single-digit nanomolar range. It uniquely combines tamoxifen or endoxifen with the EGFR inhibitor gefitinib through a covalent bo...
T74457	EGFR-IN-42
	EGFR-IN-42 (Compound 17b), a potent EGFR inhibitor, demonstrates single-digit nanomolar activity by covalently linking tamoxifen or endoxifen with gefitinib, retaining both ER antagonist activity and EGFR inhibition, res...