Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 46.00 |
Description | Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist. |
Targets&IC50 | ERG (human):1.6 μM |
In vitro | Endoxifen shows anti-estrogenic effects, and decreases the E2-induced PR expression in MCF-7 cells. [1] Endoxifen also blocks ER-alpha transcriptional activity and inhibits estrogen-induced breast cancer cell proliferation. [2] In MCF7, HS 578T, and BT-549 cells, Endoxifen significantly inhibits cell proliferation. [3] Endoxifen also exhibits four-fold higher inhibition on PKC activity compared to tamoxifen. [4] Endoxifen inhibits the hERG current by preferentially interacting with the activated states of cloned hERG potassium channels with IC50 of 1.6 μM. [5] |
In vivo | In vivo, Endoxifen (8 mg/kg, ) inhibits growth of MCF-7 human mammary tumor xenografts in mice, showing more potency than Tamoxifen. [3] |
Cell Research | MCF7 and Ishikawa cells are grown in 10% triple charcoal-stripped serum-containing medium for 3 d. The cells are then plated at a density of 2,000 cells per well in 96-well tissue culture plates and treated as indicated every 48 h. Cell proliferation assays are conducted 8 days after the first treatment using a CellTiter-Glo Luminescent Cell Viability kit according to the manufacturer's protocol.(Only for Reference) |
Synonyms | Endoxifen HCl |
Molecular Weight | 409.95 |
Formula | C25H28ClNO2 |
CAS No. | 1032008-74-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: <1 mg/mL
Ethanol: 69 mg/mL (168.3 mM)
DMSO: 69 mg/mL (168.3 mM)
You can also refer to dose conversion for different animals. More
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Endoxifen Z-isomer hydrochloride 1032008-74-4 Angiogenesis Endocrinology/Hormones JAK/STAT signaling Membrane transporter/Ion channel Tyrosine Kinase/Adaptors Estrogen/progestogen Receptor Estrogen Receptor/ERR Potassium Channel HER inhibit Inhibitor Endoxifen Z-isomer Hydrochloride Endoxifen HCl KcsA Endoxifen Z-isomer Endoxifen Z isomer hydrochloride Endoxifen Zisomer hydrochloride inhibitor